Evolution of complex molecular networks in immunity

Many traits are coordinated by complex molecular networks. Genetic variation within these networks can leads to phenotypic variation that natural selection can act upon. We will infer the gene networks that regulate Drosophila immunity against parasitoids, and functionally characterize how genetic variation within this network affects immune function. By integrating bioinformatic analyses of genomic datasets, functional genetic experiments and computational modelling, we aim to provide detailed insight in the molecular networks of immunity and how these networks are modified by adaptive evolution.