1,3,4-Oxadiazoles by Ugi-Tetrazole and Huisgen Reaction

Qian Wang, Kumchok C. Mgimpatsang, Markella Konstantinidou, Svitlana V. Shishkina, Alexander Dömling*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)
146 Downloads (Pure)

Abstract

Easy to perform, functional group tolerant, and short syntheses of the privileged scaffold oxadiazole are highly desired. Here, a metal-free protocol for MCR-based synthesis of 2,5-disubstituted 1,3,4-oxadiazoles via a Ugi-tetrazole/Huisgen sequence was developed. Optimization and scope and limitations of this short and general sequence are described. The reaction was also successfully performed on a gram scale.
Original languageEnglish
Pages (from-to)7320-7323
Number of pages4
JournalOrganic letters
Volume21
Issue number18
DOIs
Publication statusPublished - 20-Sep-2019

Keywords

  • article
  • synthesis
  • unclassified drug
  • ONE-POT
  • MULTICOMPONENT REACTIONS
  • OXADIAZOLES
  • DISCOVERY
  • CLEAVAGE

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