[15O]H2O PET: Potential or Essential for Molecular Imaging?

Riemer H J A Slart; T Samara Martinez-Lucio; Hendrikus H Boersma; Ronald H Borra; Bart Cornelissen; Rudi A J O Dierckx; Magdalena Dobrolinska; Janine Doorduin; Paola A Erba; Andor W J M Glaudemans; Bruno Lima Giacobbo; Gert Luurtsema; Walter Noordzij; Joyce van Sluis; Charalampos Tsoumpas; Adriaan A Lammertsma

doi:10.1053/j.semnuclmed.2023.08.002

[15O]H2O PET: Potential or Essential for Molecular Imaging?

Riemer H J A Slart^*, T Samara Martinez-Lucio, Hendrikus H Boersma, Ronald H Borra, Bart Cornelissen, Rudi A J O Dierckx, Magdalena Dobrolinska, Janine Doorduin, Paola A Erba, Andor W J M Glaudemans, Bruno Lima Giacobbo, Gert Luurtsema, Walter Noordzij, Joyce van Sluis, Charalampos Tsoumpas, Adriaan A Lammertsma

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

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Abstract

Imaging water pathways in the human body provides an excellent way of measuring accurately the blood flow directed to different organs. This makes it a powerful diagnostic tool for a wide range of diseases that are related to perfusion and oxygenation. Although water PET has a long history, its true potential has not made it into regular clinical practice. The article highlights the potential of water PET in molecular imaging and suggests its prospective role in becoming an essential tool for the 21st century precision medicine in different domains ranging from preclinical to clinical research and practice. The recent technical advances in high-sensitivity PET imaging can play a key accelerating role in empowering this technique, though there are still several challenges to overcome.

Original language	English
Pages (from-to)	761-773
Number of pages	13
Journal	Seminars in Nuclear Medicine
Volume	54
Issue number	5
Early online date	26-Aug-2023
DOIs	https://doi.org/10.1053/j.semnuclmed.2023.08.002
Publication status	Published - Sept-2024

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Slart, R. H. J. A., Martinez-Lucio, T. S., Boersma, H. H., Borra, R. H., Cornelissen, B., Dierckx, R. A. J. O., Dobrolinska, M., Doorduin, J., Erba, P. A., Glaudemans, A. W. J. M., Giacobbo, B. L., Luurtsema, G., Noordzij, W., van Sluis, J., Tsoumpas, C., & Lammertsma, A. A. (2024). [15O]H2O PET: Potential or Essential for Molecular Imaging? Seminars in Nuclear Medicine, 54(5), 761-773. https://doi.org/10.1053/j.semnuclmed.2023.08.002

@article{9e52009381f740adab81dfe559dab51a,

title = "[15O]H2O PET: Potential or Essential for Molecular Imaging?",

abstract = "Imaging water pathways in the human body provides an excellent way of measuring accurately the blood flow directed to different organs. This makes it a powerful diagnostic tool for a wide range of diseases that are related to perfusion and oxygenation. Although water PET has a long history, its true potential has not made it into regular clinical practice. The article highlights the potential of water PET in molecular imaging and suggests its prospective role in becoming an essential tool for the 21st century precision medicine in different domains ranging from preclinical to clinical research and practice. The recent technical advances in high-sensitivity PET imaging can play a key accelerating role in empowering this technique, though there are still several challenges to overcome.",

author = "Slart, {Riemer H J A} and Martinez-Lucio, {T Samara} and Boersma, {Hendrikus H} and Borra, {Ronald H} and Bart Cornelissen and Dierckx, {Rudi A J O} and Magdalena Dobrolinska and Janine Doorduin and Erba, {Paola A} and Glaudemans, {Andor W J M} and Giacobbo, {Bruno Lima} and Gert Luurtsema and Walter Noordzij and {van Sluis}, Joyce and Charalampos Tsoumpas and Lammertsma, {Adriaan A}",

year = "2024",

month = sep,

doi = "10.1053/j.semnuclmed.2023.08.002",

language = "English",

volume = "54",

pages = "761--773",

journal = "Seminars in Nuclear Medicine",

issn = "0001-2998",

publisher = "W B SAUNDERS CO-ELSEVIER INC",

number = "5",

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Slart, RHJA , Martinez-Lucio, TS , Boersma, HH , Borra, RH , Cornelissen, B , Dierckx, RAJO , Dobrolinska, M , Doorduin, J, Erba, PA, Glaudemans, AWJM , Giacobbo, BL , Luurtsema, G , Noordzij, W , van Sluis, J , Tsoumpas, C & Lammertsma, AA 2024, '[15O]H2O PET: Potential or Essential for Molecular Imaging?', Seminars in Nuclear Medicine, vol. 54, no. 5, pp. 761-773. https://doi.org/10.1053/j.semnuclmed.2023.08.002

TY - JOUR

T1 - [15O]H2O PET

T2 - Potential or Essential for Molecular Imaging?

AU - Slart, Riemer H J A

AU - Martinez-Lucio, T Samara

AU - Boersma, Hendrikus H

AU - Borra, Ronald H

AU - Cornelissen, Bart

AU - Dierckx, Rudi A J O

AU - Dobrolinska, Magdalena

AU - Doorduin, Janine

AU - Erba, Paola A

AU - Glaudemans, Andor W J M

AU - Giacobbo, Bruno Lima

AU - Luurtsema, Gert

AU - Noordzij, Walter

AU - van Sluis, Joyce

AU - Tsoumpas, Charalampos

AU - Lammertsma, Adriaan A

PY - 2024/9

Y1 - 2024/9

N2 - Imaging water pathways in the human body provides an excellent way of measuring accurately the blood flow directed to different organs. This makes it a powerful diagnostic tool for a wide range of diseases that are related to perfusion and oxygenation. Although water PET has a long history, its true potential has not made it into regular clinical practice. The article highlights the potential of water PET in molecular imaging and suggests its prospective role in becoming an essential tool for the 21st century precision medicine in different domains ranging from preclinical to clinical research and practice. The recent technical advances in high-sensitivity PET imaging can play a key accelerating role in empowering this technique, though there are still several challenges to overcome.

AB - Imaging water pathways in the human body provides an excellent way of measuring accurately the blood flow directed to different organs. This makes it a powerful diagnostic tool for a wide range of diseases that are related to perfusion and oxygenation. Although water PET has a long history, its true potential has not made it into regular clinical practice. The article highlights the potential of water PET in molecular imaging and suggests its prospective role in becoming an essential tool for the 21st century precision medicine in different domains ranging from preclinical to clinical research and practice. The recent technical advances in high-sensitivity PET imaging can play a key accelerating role in empowering this technique, though there are still several challenges to overcome.

U2 - 10.1053/j.semnuclmed.2023.08.002

DO - 10.1053/j.semnuclmed.2023.08.002

M3 - Review article

C2 - 37640631

SN - 0001-2998

VL - 54

SP - 761

EP - 773

JO - Seminars in Nuclear Medicine

JF - Seminars in Nuclear Medicine

IS - 5

ER -

[15O]H2O PET: Potential or Essential for Molecular Imaging?

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