18F-FDG-PET/CT imaging of uterine cervical cancer recurrence in women with and without HIV infection

Ismaheel O. Lawal; Kehinde O. Ololade; Gbenga O. Popoola; Alfred O. Ankrah; Mariza Vorster; Alex Maes; Neo P. Mokgoro; Christophe van de Wiele; Mike M. Sathekge

doi:10.23736/S1824-4785.19.03156-X

18F-FDG-PET/CT imaging of uterine cervical cancer recurrence in women with and without HIV infection

Ismaheel O. Lawal, Kehinde O. Ololade, Gbenga O. Popoola, Alfred O. Ankrah, Mariza Vorster, Alex Maes, Neo P. Mokgoro, Christophe van de Wiele, Mike M. Sathekge^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

Abstract

BACKGROUND: To compare the rate, time and, pattern of recurrence of cervical cancer between patients with and without HIV infection and to determine factors predicting cervical cancer recurrence in patients evaluated by F-18-FDG-PET/CT.

METHODS: We reviewed the F-18-FDG-PET/CT images of patients with histologically proven cervical carcinoma who were presenting with suspected recurrence. We extracted epidemiologic data, previous treatment. histologic subtype, HIV status, viral load and CD4 counts from the electronic laboratory database and the referral form for the F-18-FDG-PET/CT study.

RESULTS: We studied 303 women including 112 HIV-infected patients. FIGO stage III disease was present in 131 patients. Of 198 patients with recurrence, 74 were HIV-infected while 124 were not (P=0.849). HIV infected patients were younger (41.99 +/- 9.30 years) compared to HIV-uninfected (50.19 +/- 11.09), P

CONCLUSIONS: HIV infection has no significant impact on the rate, time or pattern of recurrence in women with suspected cervical carcinoma recurrence. Advanced disease and histological variant other than SCC are predictive of recurrence.

Original language	English
Pages (from-to)	52-60
Number of pages	9
Journal	Quarterly Journal of Nuclear Medicine and Molecular Imaging
Volume	66
Issue number	1
DOIs	https://doi.org/10.23736/S1824-4785.19.03156-X
Publication status	Published - Mar-2022

Keywords

Fluorodeoxyglucose F18
Positron emission tomography computed tomography
Uterine cervical neoplasms
Carcinoma
squamous cell
Recurrence
HIV infections
SQUAMOUS-CELL CARCINOMA
CONCURRENT CHEMORADIOTHERAPY
F-18-FDG PET/CT
FDG PET/CT
THERAPY
CHEMOTHERAPY
MALIGNANCIES
SURVIVAL
IMPACT

Access to Document

10.23736/S1824-4785.19.03156-X

Handle.net

Persistent link

Cite this

@article{f184acc176c44dca8de7c513db9273b4,

title = "18F-FDG-PET/CT imaging of uterine cervical cancer recurrence in women with and without HIV infection",

abstract = "BACKGROUND: To compare the rate, time and, pattern of recurrence of cervical cancer between patients with and without HIV infection and to determine factors predicting cervical cancer recurrence in patients evaluated by F-18-FDG-PET/CT.METHODS: We reviewed the F-18-FDG-PET/CT images of patients with histologically proven cervical carcinoma who were presenting with suspected recurrence. We extracted epidemiologic data, previous treatment. histologic subtype, HIV status, viral load and CD4 counts from the electronic laboratory database and the referral form for the F-18-FDG-PET/CT study.RESULTS: We studied 303 women including 112 HIV-infected patients. FIGO stage III disease was present in 131 patients. Of 198 patients with recurrence, 74 were HIV-infected while 124 were not (P=0.849). HIV infected patients were younger (41.99 +/- 9.30 years) compared to HIV-uninfected (50.19 +/- 11.09), PCONCLUSIONS: HIV infection has no significant impact on the rate, time or pattern of recurrence in women with suspected cervical carcinoma recurrence. Advanced disease and histological variant other than SCC are predictive of recurrence.",

keywords = "Fluorodeoxyglucose F18, Positron emission tomography computed tomography, Uterine cervical neoplasms, Carcinoma, squamous cell, Recurrence, HIV infections, SQUAMOUS-CELL CARCINOMA, CONCURRENT CHEMORADIOTHERAPY, F-18-FDG PET/CT, FDG PET/CT, THERAPY, CHEMOTHERAPY, MALIGNANCIES, SURVIVAL, IMPACT",

author = "Lawal, {Ismaheel O.} and Ololade, {Kehinde O.} and Popoola, {Gbenga O.} and Ankrah, {Alfred O.} and Mariza Vorster and Alex Maes and Mokgoro, {Neo P.} and {van de Wiele}, Christophe and Sathekge, {Mike M.}",

year = "2022",

month = mar,

doi = "10.23736/S1824-4785.19.03156-X",

language = "English",

volume = "66",

pages = "52--60",

journal = "Quarterly Journal of Nuclear Medicine and Molecular Imaging",

issn = "1824-4661",

publisher = "EDIZIONI MINERVA MEDICA",

number = "1",

}

TY - JOUR

T1 - 18F-FDG-PET/CT imaging of uterine cervical cancer recurrence in women with and without HIV infection

AU - Lawal, Ismaheel O.

AU - Ololade, Kehinde O.

AU - Popoola, Gbenga O.

AU - Ankrah, Alfred O.

AU - Vorster, Mariza

AU - Maes, Alex

AU - Mokgoro, Neo P.

AU - van de Wiele, Christophe

AU - Sathekge, Mike M.

PY - 2022/3

Y1 - 2022/3

N2 - BACKGROUND: To compare the rate, time and, pattern of recurrence of cervical cancer between patients with and without HIV infection and to determine factors predicting cervical cancer recurrence in patients evaluated by F-18-FDG-PET/CT.METHODS: We reviewed the F-18-FDG-PET/CT images of patients with histologically proven cervical carcinoma who were presenting with suspected recurrence. We extracted epidemiologic data, previous treatment. histologic subtype, HIV status, viral load and CD4 counts from the electronic laboratory database and the referral form for the F-18-FDG-PET/CT study.RESULTS: We studied 303 women including 112 HIV-infected patients. FIGO stage III disease was present in 131 patients. Of 198 patients with recurrence, 74 were HIV-infected while 124 were not (P=0.849). HIV infected patients were younger (41.99 +/- 9.30 years) compared to HIV-uninfected (50.19 +/- 11.09), PCONCLUSIONS: HIV infection has no significant impact on the rate, time or pattern of recurrence in women with suspected cervical carcinoma recurrence. Advanced disease and histological variant other than SCC are predictive of recurrence.

AB - BACKGROUND: To compare the rate, time and, pattern of recurrence of cervical cancer between patients with and without HIV infection and to determine factors predicting cervical cancer recurrence in patients evaluated by F-18-FDG-PET/CT.METHODS: We reviewed the F-18-FDG-PET/CT images of patients with histologically proven cervical carcinoma who were presenting with suspected recurrence. We extracted epidemiologic data, previous treatment. histologic subtype, HIV status, viral load and CD4 counts from the electronic laboratory database and the referral form for the F-18-FDG-PET/CT study.RESULTS: We studied 303 women including 112 HIV-infected patients. FIGO stage III disease was present in 131 patients. Of 198 patients with recurrence, 74 were HIV-infected while 124 were not (P=0.849). HIV infected patients were younger (41.99 +/- 9.30 years) compared to HIV-uninfected (50.19 +/- 11.09), PCONCLUSIONS: HIV infection has no significant impact on the rate, time or pattern of recurrence in women with suspected cervical carcinoma recurrence. Advanced disease and histological variant other than SCC are predictive of recurrence.

KW - Fluorodeoxyglucose F18

KW - Positron emission tomography computed tomography

KW - Uterine cervical neoplasms

KW - Carcinoma

KW - squamous cell

KW - Recurrence

KW - HIV infections

KW - SQUAMOUS-CELL CARCINOMA

KW - CONCURRENT CHEMORADIOTHERAPY

KW - F-18-FDG PET/CT

KW - FDG PET/CT

KW - THERAPY

KW - CHEMOTHERAPY

KW - MALIGNANCIES

KW - SURVIVAL

KW - IMPACT

U2 - 10.23736/S1824-4785.19.03156-X

DO - 10.23736/S1824-4785.19.03156-X

M3 - Article

SN - 1824-4661

VL - 66

SP - 52

EP - 60

JO - Quarterly Journal of Nuclear Medicine and Molecular Imaging

JF - Quarterly Journal of Nuclear Medicine and Molecular Imaging

IS - 1

ER -