18F-FDG-PET/CT imaging of uterine cervical cancer recurrence in women with and without HIV infection

Ismaheel O. Lawal, Kehinde O. Ololade, Gbenga O. Popoola, Alfred O. Ankrah, Mariza Vorster, Alex Maes, Neo P. Mokgoro, Christophe van de Wiele, Mike M. Sathekge*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    2 Citations (Scopus)


    BACKGROUND: To compare the rate, time and, pattern of recurrence of cervical cancer between patients with and without HIV infection and to determine factors predicting cervical cancer recurrence in patients evaluated by F-18-FDG-PET/CT.

    METHODS: We reviewed the F-18-FDG-PET/CT images of patients with histologically proven cervical carcinoma who were presenting with suspected recurrence. We extracted epidemiologic data, previous treatment. histologic subtype, HIV status, viral load and CD4 counts from the electronic laboratory database and the referral form for the F-18-FDG-PET/CT study.

    RESULTS: We studied 303 women including 112 HIV-infected patients. FIGO stage III disease was present in 131 patients. Of 198 patients with recurrence, 74 were HIV-infected while 124 were not (P=0.849). HIV infected patients were younger (41.99 +/- 9.30 years) compared to HIV-uninfected (50.19 +/- 11.09), P

    CONCLUSIONS: HIV infection has no significant impact on the rate, time or pattern of recurrence in women with suspected cervical carcinoma recurrence. Advanced disease and histological variant other than SCC are predictive of recurrence.

    Original languageEnglish
    Pages (from-to)52-60
    Number of pages9
    JournalQuarterly Journal of Nuclear Medicine and Molecular Imaging
    Issue number1
    Publication statusPublished - Mar-2022


    • Fluorodeoxyglucose F18
    • Positron emission tomography computed tomography
    • Uterine cervical neoplasms
    • Carcinoma
    • squamous cell
    • Recurrence
    • HIV infections
    • F-18-FDG PET/CT
    • FDG PET/CT
    • IMPACT

    Cite this