1ST-TRIMESTER MATERNAL SERUM HUMAN CHORIONIC-GONADOTROPIN AS A MARKER FOR FETAL CHROMOSOMAL DISORDERS

JMM VANLITH*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Scopus)

Abstract

The Dutch Working Party on Prenatal Diagnosis has initiated a study on the possibilities of first-trimester screening for fetal chromosomal disorders. We report on maternal serum human chorionic gonadotrophin (MS-hCG) measurements in 1348 pregnancies with a chromosomally normal fetus and 53 pregnancies with a chromosomally abnormal fetus. The median MS-hCG concentration in 24 pregnancies with Down's syndrome was 1.19 multiples of the normal median (MoM). The MS-hCG distributions in normal and Down's syndrome pregnancies did not differ significantly (t-test: t = 1.945,p > 0.05). We also found no difference between normal pregnancies and pregnancies with other chromosomal disorders (six cases of trisomy 18, MoM = 0.80; four cases of sex chromosome abnormality, MoM = 1.01; 17 cases of chromosomal mosaicism in chorionic villi, MoM = 1.11). Selecting an upper limit at the 90th centile could detect 25 per cent of pregnancies with Down's syndrome. We conclude that, in the first trimester, MS-hCG as a screening factor for Down's syndrome is of minor value. However, MS-hCG could be a useful factor in a first-trimester screening programme based on a combination of markers.

Original languageEnglish
Pages (from-to)495-504
Number of pages10
JournalPrenatal Diagnosis
Volume12
Issue number6
Publication statusPublished - Jun-1992

Keywords

  • HUMAN CHORIONIC GONADOTROPIN
  • 1ST-TRIMESTER SCREENING
  • FETAL CHROMOSOMAL DISORDER
  • DOWNS SYNDROME
  • DOWNS-SYNDROME
  • ALPHA-FETOPROTEIN
  • PREGNANCIES

Cite this