2-Nitrobenzyl Isocyanide as a Universal Convertible Isocyanide

Ajay L. Chandgude, Jingyao Li, Alexander Domling*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Abstract

2-Nitrobenzyl isocyanide is reported as a universal convertible isocyanide with extensive applicability in both Ugi four-component reaction (Ugi-4CR) and Ugi-tetrazole reaction. The cleavage of this isocyanide from 17examples in both acidic and basic conditions is presented. Additionally, this isocyanide has various handling and synthetic advantages, as it is easy to prepare, odorless, stable, and easy to handle as a solid.

Original languageEnglish
Pages (from-to)798-801
Number of pages4
JournalAsian Journal of Organic Chemistry
Volume6
Issue number7
DOIs
Publication statusPublished - Jul-2017

Keywords

  • convertible isocyanide
  • multicomponent reactions
  • tetrazole
  • ugi-4cr
  • ugi-tetrazole reaction
  • MULTICOMPONENT REACTIONS
  • REACTION-MECHANISMS
  • PROTECTING GROUPS
  • UGI REACTION
  • CHEMISTRY
  • ISONITRILES
  • DERIVATIVES
  • EQUIVALENT
  • VERSATILE
  • BIOLOGY

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