6-CARBOXYMETHYL-2-AZABICYCLO[2.2.1]HEPTANE ENANTIOMERS - MUSCARINIC ACTIVITIES OF RIGID ANALOGS OF ARECOLINE

E POMBOVILLAR*, P SUPAVILAI, HP WEBER, HWGM BODDEKE

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

(1R,4R,6R)-(-)-6-Carbomethoxy-2-azabicyclo[2.2.1]heptane 8a, (1R,4R,6R)-(-)-6-carbomethoxy-2-methyl-2-azabicyclo[2.2.l]heptane 2a and their enantiomers 8b and 2b have been prepared as rigid analogues of the enantiomorphic conformations of arecoline, and their activities as muscarinic agonists evaluated.

Original languageEnglish
Pages (from-to)501-504
Number of pages4
JournalBioorganic & Medicinal Chemistry Letters
Volume2
Issue number5
Publication statusPublished - May-1992

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