6-carboxymethyl-2-azabicyclo[2.2.1]heptane enantiomers: Muscarinic activities of rigid analogues of arecoline

E. Pombo-Villar; P. Supavilai; H.P. Weber; H.W.G.M. Boddeke

doi:10.1016/S0960-894X(00)80178-X

6-carboxymethyl-2-azabicyclo[2.2.1]heptane enantiomers: Muscarinic activities of rigid analogues of arecoline

E. Pombo-Villar, P. Supavilai, H.P. Weber, H.W.G.M. Boddeke

Translational Immunology Groningen (TRIGR)

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Scopus)

Abstract

(1R,4R,6R)-(-)-6-carbomethoxy-2-azabicyclo[2.2.1]heptane 8a, (1R,4R,6R)-(-)-6-carbomethoxy-2-methyl-2-azabicyclo[2.2.1]heptane 2a and their enantiomers 8b and 2b have been prepared as rigid analogues of the enantiomorphic conformations of arecoline, and their activities as muscarinic agonists evaluated.

Original language	English
Pages (from-to)	501-504
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	2
Issue number	5
DOIs	https://doi.org/10.1016/S0960-894X(00)80178-X
Publication status	Published - 12-Nov-1992

Keywords

arecoline
muscarinic agent
muscarinic receptor
norbornane derivative
animal tissue
article
brain
controlled study
drug synthesis
enantiomer
guinea pig
ileum
nonhuman
rat

Access to Document

10.1016/S0960-894X(00)80178-X

Cite this

@article{37ff6a84f5b643ad8135a209b7bf69d8,

title = "6-carboxymethyl-2-azabicyclo[2.2.1]heptane enantiomers: Muscarinic activities of rigid analogues of arecoline",

abstract = "(1R,4R,6R)-(-)-6-carbomethoxy-2-azabicyclo[2.2.1]heptane 8a, (1R,4R,6R)-(-)-6-carbomethoxy-2-methyl-2-azabicyclo[2.2.1]heptane 2a and their enantiomers 8b and 2b have been prepared as rigid analogues of the enantiomorphic conformations of arecoline, and their activities as muscarinic agonists evaluated.",

keywords = "arecoline, muscarinic agent, muscarinic receptor, norbornane derivative, animal tissue, article, brain, controlled study, drug synthesis, enantiomer, guinea pig, ileum, nonhuman, rat",

author = "E. Pombo-Villar and P. Supavilai and H.P. Weber and H.W.G.M. Boddeke",

year = "1992",

month = nov,

day = "12",

doi = "10.1016/S0960-894X(00)80178-X",

language = "English",

volume = "2",

pages = "501--504",

journal = "Bioorganic & Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "American Chemical Society",

number = "5",

}

TY - JOUR

T1 - 6-carboxymethyl-2-azabicyclo[2.2.1]heptane enantiomers: Muscarinic activities of rigid analogues of arecoline

AU - Pombo-Villar, E.

AU - Supavilai, P.

AU - Weber, H.P.

AU - Boddeke, H.W.G.M.

PY - 1992/11/12

Y1 - 1992/11/12

N2 - (1R,4R,6R)-(-)-6-carbomethoxy-2-azabicyclo[2.2.1]heptane 8a, (1R,4R,6R)-(-)-6-carbomethoxy-2-methyl-2-azabicyclo[2.2.1]heptane 2a and their enantiomers 8b and 2b have been prepared as rigid analogues of the enantiomorphic conformations of arecoline, and their activities as muscarinic agonists evaluated.

AB - (1R,4R,6R)-(-)-6-carbomethoxy-2-azabicyclo[2.2.1]heptane 8a, (1R,4R,6R)-(-)-6-carbomethoxy-2-methyl-2-azabicyclo[2.2.1]heptane 2a and their enantiomers 8b and 2b have been prepared as rigid analogues of the enantiomorphic conformations of arecoline, and their activities as muscarinic agonists evaluated.

KW - arecoline

KW - muscarinic agent

KW - muscarinic receptor

KW - norbornane derivative

KW - animal tissue

KW - article

KW - brain

KW - controlled study

KW - drug synthesis

KW - enantiomer

KW - guinea pig

KW - ileum

KW - nonhuman

KW - rat

U2 - 10.1016/S0960-894X(00)80178-X

DO - 10.1016/S0960-894X(00)80178-X

M3 - Article

VL - 2

SP - 501

EP - 504

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

SN - 0960-894X

IS - 5

ER -