6-carboxymethyl-2-azabicyclo[2.2.1]heptane enantiomers: Muscarinic activities of rigid analogues of arecoline

E. Pombo-Villar, P. Supavilai, H.P. Weber, H.W.G.M. Boddeke

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6 Citations (Scopus)

Abstract

(1R,4R,6R)-(-)-6-carbomethoxy-2-azabicyclo[2.2.1]heptane 8a, (1R,4R,6R)-(-)-6-carbomethoxy-2-methyl-2-azabicyclo[2.2.1]heptane 2a and their enantiomers 8b and 2b have been prepared as rigid analogues of the enantiomorphic conformations of arecoline, and their activities as muscarinic agonists evaluated.
Original languageEnglish
Pages (from-to)501-504
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume2
Issue number5
DOIs
Publication statusPublished - 12-Nov-1992

Keywords

  • arecoline
  • muscarinic agent
  • muscarinic receptor
  • norbornane derivative
  • animal tissue
  • article
  • brain
  • controlled study
  • drug synthesis
  • enantiomer
  • guinea pig
  • ileum
  • nonhuman
  • rat

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