6-Hydroxy-2,5,7,8-tetramethylchroman-compounds for the treatment of chronic obstructive airway diseases

Adrianus Cornelis van der Graaf (Inventor), Martina Schmidt (Inventor), Gerrit Jan Willem Euverink (Inventor), Hermanus Meurs (Inventor), Robert Henk Henning (Inventor)

Research output: Patent

Abstract

The present invention relates to compounds for the treatment of chronic obstructive airway diseases such as chronic obstructive pulmonary disease (COPD) or asthma or bronchiectasis. The present invention further relates to drug delivery devices suitable to be used in the treatment of chronic obstructive airway diseases such as a nebulizer comprising the present compounds. Specifically, the present invention relates to (6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)(piperazin-1-yl)methanone or N,6-di-hydroxy-2,5,7,8-tetramethylchroman-2-carboxamide or a pharmaceutically acceptable salt or base thereof for use in the treatment of chronic obstructive airway diseases, preferably chronic obstructive pulmonary disease (COPD) or asthma or bronchiectasis, more preferably chronic obstructive pulmonary disease (COPD).
Original languageEnglish
Patent numberWO2015193365
Priority date17/06/2014
Publication statusPublished - 23-Dec-2015

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