A 12-month follow-up study of treating overweight schizophrenic patients with aripiprazole

S. G. Schorr, C. J. Slooff, R. Postema, W. Van Oven, M. Schilthuis, R. Bruggeman, K. Taxis*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)
226 Downloads (Pure)

Abstract

Objective: To investigate the feasibility of switching overweight schizophrenic patients to aripiprazole and to assess the impact of 12 months of aripiprazole treatment on weight in routine practice.

Method: This was a non-controlled cohort study in overweight schizophrenic patients. Data were collected before treatment with aripiprazole was started and at 12-month follow-up.

Results: A total of 53 patients were included; of these 55% continued using aripiprazole for 12 months. Aripiprazole treatment for 12 months (P = 0.027) and stopping clozapine or olanzapine treatment (P = 0.038) predicted weight loss (>= 3 kg). Patients receiving aripiprazole monotherapy (n = 16, mean -3.0 kg) had similar weight loss than patients receiving aripiprazole in addition to another antipsychotic drug (n = 13, mean -4.4 kg).

Conclusion: In routine practice once aripiprazole treatment was started, more than half of the patients remained on aripiprazole and most of them lost weight. Adding aripiprazole to clozapine gave similar weight loss as monotherapy with aripiprazole.

Original languageEnglish
Pages (from-to)246-250
Number of pages5
JournalActa Psychiatrica Scandinavica
Volume118
Issue number3
DOIs
Publication statusPublished - Sep-2008

Keywords

  • aripiprazole
  • schizophrenia
  • antipsychotic agents
  • overweight
  • body weight changes
  • OPEN-LABEL
  • WEIGHT-GAIN
  • MULTICENTER
  • THERAPY
  • TRIAL
  • OLANZAPINE
  • SAFETY
  • TERM

Cite this