A case report of phenytoin encephalopathy: Correlation between serum levels, seizure increase and E.E.G. spike and wave activity

Machiel J Zwarts; O Sie

doi:10.1016/0303-8467(85)90008-3

A case report of phenytoin encephalopathy: Correlation between serum levels, seizure increase and E.E.G. spike and wave activity

Machiel J Zwarts^*, O Sie

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

In a case of phenytoin (PHT) encephalopathy a correlation was found between rising PHT serum levels and increase in seizure frequency. Supporting the correlation was the concomitant increase of E.E.G. spike and wave activity to 25% of the registration time. The rise in the PHT serum levels was possibly related to a drug interaction with carbamazepine.
In addition neuropsychological assessment indicated reversible mental deterioration and deficits in motor skills and visual perception

Original language	English
Pages (from-to)	205-208
Number of pages	4
Journal	Clinical neurology and neurosurgery
Volume	87
Issue number	3
DOIs	https://doi.org/10.1016/0303-8467(85)90008-3
Publication status	Published - 1985

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@article{29620693990c411c9cbc923d7e4e1e7e,

title = "A case report of phenytoin encephalopathy: Correlation between serum levels, seizure increase and E.E.G. spike and wave activity",

abstract = "In a case of phenytoin (PHT) encephalopathy a correlation was found between rising PHT serum levels and increase in seizure frequency. Supporting the correlation was the concomitant increase of E.E.G. spike and wave activity to 25% of the registration time. The rise in the PHT serum levels was possibly related to a drug interaction with carbamazepine.In addition neuropsychological assessment indicated reversible mental deterioration and deficits in motor skills and visual perception",

author = "Zwarts, {Machiel J} and O Sie",

year = "1985",

doi = "10.1016/0303-8467(85)90008-3",

language = "English",

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pages = "205--208",

journal = "Clinical neurology and neurosurgery",

issn = "0303-8467",

publisher = "ELSEVIER SCIENCE BV",

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T1 - A case report of phenytoin encephalopathy

T2 - Correlation between serum levels, seizure increase and E.E.G. spike and wave activity

AU - Zwarts, Machiel J

AU - Sie, O

PY - 1985

Y1 - 1985

N2 - In a case of phenytoin (PHT) encephalopathy a correlation was found between rising PHT serum levels and increase in seizure frequency. Supporting the correlation was the concomitant increase of E.E.G. spike and wave activity to 25% of the registration time. The rise in the PHT serum levels was possibly related to a drug interaction with carbamazepine.In addition neuropsychological assessment indicated reversible mental deterioration and deficits in motor skills and visual perception

AB - In a case of phenytoin (PHT) encephalopathy a correlation was found between rising PHT serum levels and increase in seizure frequency. Supporting the correlation was the concomitant increase of E.E.G. spike and wave activity to 25% of the registration time. The rise in the PHT serum levels was possibly related to a drug interaction with carbamazepine.In addition neuropsychological assessment indicated reversible mental deterioration and deficits in motor skills and visual perception

U2 - 10.1016/0303-8467(85)90008-3

DO - 10.1016/0303-8467(85)90008-3

M3 - Article

SN - 0303-8467

VL - 87

SP - 205

EP - 208

JO - Clinical neurology and neurosurgery

JF - Clinical neurology and neurosurgery

IS - 3

ER -

A case report of phenytoin encephalopathy: Correlation between serum levels, seizure increase and E.E.G. spike and wave activity

Abstract

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