TY - JOUR
T1 - A catalytic and iterative route to β-substituted esters via highly enantioselective conjugate addition of dimethylzinc to unsaturated malonates
AU - Schuppan, Julia
AU - Minnaard, Adriaan J.
AU - Feringa, Bernard
N1 - Relation: http://www.rug.nl/scheikunde/
date_submitted:2005
Rights: University of Groningen. Stratingh Institute
PY - 2004
Y1 - 2004
N2 - Using the chiral phosphoramidite ligand (S,R,R)-L1 in the conjugate addition of dimethylzinc to acyclic unsaturated malonates, enantioselectivities of up to 98% have been obtained for the first time. An iterative and stereodivergent route to 3,5-dimethyl esters that takes advantage of this asymmetric catalysis has been developed.
AB - Using the chiral phosphoramidite ligand (S,R,R)-L1 in the conjugate addition of dimethylzinc to acyclic unsaturated malonates, enantioselectivities of up to 98% have been obtained for the first time. An iterative and stereodivergent route to 3,5-dimethyl esters that takes advantage of this asymmetric catalysis has been developed.
U2 - 10.1002/chin.200433086
DO - 10.1002/chin.200433086
M3 - Article
VL - 35
JO - ChemInform
JF - ChemInform
IS - 33
ER -