A comparative PET study using different 11C-labelled amino acids in Walker 256 carcinosarcoma-bearing rats

B.J.G. Daemen*, P.H. Elsinga, K. Ishiwata, A.M.J. Paans, W. Vaalburg

*Corresponding author for this work

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    13 Citations (Scopus)

    Abstract

    In Walker 256 carcinosarcoma-bearing rats, the dynamic distribution of L-[1-C-11]tyrosine, L-[methyl-C-11]methionine, L-[1-C-11]methionine and D-[1-C-11]methionine has been measured by PET. An equivalent tumor-imaging potential was observed for each of the three L-amino acids. Thirty minutes after injection, the tumors accumulated 57% (P <0.01) more C-11-activity from L-[1-C-11]methionine than from L-[metyl-C-11]methionine. At the same point of time, the livers showed a 33% (P <0.001) higher C-11-uptake with L-[methyl-C-11]methionine than with L-[1-C-11]methionine. The dynamic tissue data are in agreement with the findings in experiments with C-14-analogs.

    Original languageEnglish
    Pages (from-to)197-204
    Number of pages8
    JournalNuclear Medicine and Biology
    Volume18
    Issue number2
    DOIs
    Publication statusPublished - 1991

    Keywords

    • POSITRON EMISSION TOMOGRAPHY
    • PROTEIN-SYNTHESIS RATES
    • C-11 LABELED TYROSINE
    • L-METHIONINE
    • METABOLISM

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