A computational study on the nature of DNA G-quadruplex structure

Research output: ThesisThesis fully internal (DIV)

22 Downloads (Pure)

Abstract

DNA G-quadruplexes are higher-order structures self-assembled from guanine-rich oligonucleotides.
These DNA structures are composed of stacked planar G-quartets, a cyclic Hoogsteen
hydrogen bonding arrangement of four guanine bases, that are stabilized in the
presence of monovalent cations. The identification of G-quadruplex structures in the
human genome, particularly telomeres and oncogene-promoter regions offer unique avenues to selectively target these structures for anticancer drug development. In addition, G-quadruplex structures have attracted considerable attention for their regulatory roles in cellular processes including DNA replication, transcription, and translation. Apart from the therapeutics and biology, the unique structure of the G-quadruplex makes it an interesting building blocks for the development of nanodevices. The aim of this thesis is to investigate different aspects of G-quadruplex based systems for these applications with the aid of computational techniques.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • University of Groningen
Supervisors/Advisors
  • Faraji, Shirin, Supervisor
  • Marrink, Siewert, Supervisor
  • de Vries, Alex, Co-supervisor
  • Dreuw, Andreas, Assessment committee, External person
  • Borschevsky, Anastasia, Assessment committee
  • Chiechi, Ryan, Assessment committee
Award date19-Mar-2021
Place of Publication[Groningen]
Publisher
DOIs
Publication statusPublished - 2021

Cite this