A dynamic course of T cell defects in individuals at risk for mood disorders

G. Snijders*, C. Schiweck, E. Mesman, L. Grosse, H. De Wit, W. A. Nolen, H. A. Drexhage, M. H. J. Hillegers

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Scopus)

Abstract

Objectives: T cell abnormalities have been repeatedly reported in adult patients with mood disorders, suggesting a role of these cells in the pathogenesis of these disorders. In the present study, we explored the dynamics of circulating T cell subsets over time in a population at high familial risk for developing a mood disorder.

Methods: Children of a parent with bipolar disorder (bipolar offspring, N = 140) were assessed at three time-points: adolescence, young adulthood and adulthood. We carried out a detailed fluorescence activated cell sorting (FACS) analysis to determine various T cell subsets from frozen stored peripheral blood mononuclear cells of bipolar offspring and age- and gender-matched healthy controls at each time-point.

Results: Throughout the period of observation reduced levels of CD3+ and CD3+ CD4+ T cells were observed. In bipolar offspring T(h)1, T(h)2, T(h)17 and natural T regulatory cells (T-regs) followed a dynamic course over time with reduced levels of T, in adolescence and a reduced relative number of T(h)1, T(h)17 cells in young adulthood. In post hoc analysis T-regs were inversely associated with the pro inflammatory monocyte state determined previously (r(s)=-0.220, p = 0.001). Significant associations between T cell subset abnormalities and psychopathology such as mood disorders were not found.

Conclusions: A subtle partial T cell defect was present in bipolar offspring from adolescence through adulthood. Within this defect the dynamic change of inflammatory and regulatory T cell subsets suggests a high inflammatory state during adolescence, a reduced inflammatory state during young adulthood and a virtually normalized state at adulthood. (C) 2016 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)11-17
Number of pages7
JournalBrain behavior and immunity
Volume58
DOIs
Publication statusPublished - Nov-2016

Keywords

  • T cells
  • Natural T regulatory cells
  • Inflammation
  • Gene expression
  • High risk
  • Mood disorder
  • Bipolar disorder
  • 22Q11.2 DELETION SYNDROME
  • BIPOLAR DISORDER
  • AUTOIMMUNE-DISEASES
  • DEPRESSION
  • IMMUNITY
  • SCHIZOPHRENIA
  • TOLERANCE
  • MONOCYTE
  • CHILDREN
  • BALANCE

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