A GENE IN THE CHROMOSOMAL REGION 3P21 WITH GREATLY REDUCED EXPRESSION IN LUNG-CANCER IS SIMILAR TO THE GENE FOR UBIQUITIN-ACTIVATING ENZYME

K KOK*, R HOFSTRA, A PILZ, Anke van den Berg, P TERPSTRA, CHCM BUYS, B CARRITT

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

The chromosomal region 3p21 is thought to be the site of a lung tumor suppressor gene. We recently cloned a gene from this region that has greatly reduced expression in almost all lung tumor cell lines examined, in spite of being widely expressed in a variety of other tumor and nontumor cell types. We report here the sequence of this gene and show that it has significant homology to the genes encoding the ubiquitin-activating enzymes of three species, including humans. This suggests it is a second, autosomal member of this gene family in humans and may play a role in the ubiquitin conjugation pathway, which is of central importance in all eukaryotes.

Original languageEnglish
Pages (from-to)6071-6075
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume90
Issue number13
Publication statusPublished - 1-Jul-1993

Keywords

  • MOUSE Y-CHROMOSOME
  • CYCLE MUTANT TS85
  • L-CELL DEFECT
  • MOLECULAR-CLONING
  • ESCHERICHIA-COLI
  • DNA-REPLICATION
  • SEQUENCE
  • PROTEIN

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