A GENE IN THE CHROMOSOMAL REGION 3P21 WITH GREATLY REDUCED EXPRESSION IN LUNG-CANCER IS SIMILAR TO THE GENE FOR UBIQUITIN-ACTIVATING ENZYME

K KOK; R HOFSTRA; A PILZ; Anke van den Berg; P TERPSTRA; CHCM BUYS; B CARRITT

A GENE IN THE CHROMOSOMAL REGION 3P21 WITH GREATLY REDUCED EXPRESSION IN LUNG-CANCER IS SIMILAR TO THE GENE FOR UBIQUITIN-ACTIVATING ENZYME

K KOK^*, R HOFSTRA, A PILZ, Anke van den Berg, P TERPSTRA, CHCM BUYS, B CARRITT

^*Corresponding author for this work

Translational Immunology Groningen (TRIGR)

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Abstract

The chromosomal region 3p21 is thought to be the site of a lung tumor suppressor gene. We recently cloned a gene from this region that has greatly reduced expression in almost all lung tumor cell lines examined, in spite of being widely expressed in a variety of other tumor and nontumor cell types. We report here the sequence of this gene and show that it has significant homology to the genes encoding the ubiquitin-activating enzymes of three species, including humans. This suggests it is a second, autosomal member of this gene family in humans and may play a role in the ubiquitin conjugation pathway, which is of central importance in all eukaryotes.

Original language	English
Pages (from-to)	6071-6075
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	90
Issue number	13
Publication status	Published - 1-Jul-1993

Keywords

MOUSE Y-CHROMOSOME
CYCLE MUTANT TS85
L-CELL DEFECT
MOLECULAR-CLONING
ESCHERICHIA-COLI
DNA-REPLICATION
SEQUENCE
PROTEIN

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title = "A GENE IN THE CHROMOSOMAL REGION 3P21 WITH GREATLY REDUCED EXPRESSION IN LUNG-CANCER IS SIMILAR TO THE GENE FOR UBIQUITIN-ACTIVATING ENZYME",

abstract = "The chromosomal region 3p21 is thought to be the site of a lung tumor suppressor gene. We recently cloned a gene from this region that has greatly reduced expression in almost all lung tumor cell lines examined, in spite of being widely expressed in a variety of other tumor and nontumor cell types. We report here the sequence of this gene and show that it has significant homology to the genes encoding the ubiquitin-activating enzymes of three species, including humans. This suggests it is a second, autosomal member of this gene family in humans and may play a role in the ubiquitin conjugation pathway, which is of central importance in all eukaryotes.",

keywords = "MOUSE Y-CHROMOSOME, CYCLE MUTANT TS85, L-CELL DEFECT, MOLECULAR-CLONING, ESCHERICHIA-COLI, DNA-REPLICATION, SEQUENCE, PROTEIN",

author = "K KOK and R HOFSTRA and A PILZ and {van den Berg}, Anke and P TERPSTRA and CHCM BUYS and B CARRITT",

year = "1993",

month = jul,

day = "1",

language = "English",

volume = "90",

pages = "6071--6075",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "NATL ACAD SCIENCES",

number = "13",

}

A GENE IN THE CHROMOSOMAL REGION 3P21 WITH GREATLY REDUCED EXPRESSION IN LUNG-CANCER IS SIMILAR TO THE GENE FOR UBIQUITIN-ACTIVATING ENZYME. / KOK, K; HOFSTRA, R; PILZ, A et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, No. 13, 01.07.1993, p. 6071-6075.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - A GENE IN THE CHROMOSOMAL REGION 3P21 WITH GREATLY REDUCED EXPRESSION IN LUNG-CANCER IS SIMILAR TO THE GENE FOR UBIQUITIN-ACTIVATING ENZYME

AU - KOK, K

AU - HOFSTRA, R

AU - PILZ, A

AU - van den Berg, Anke

AU - TERPSTRA, P

AU - BUYS, CHCM

AU - CARRITT, B

PY - 1993/7/1

Y1 - 1993/7/1

N2 - The chromosomal region 3p21 is thought to be the site of a lung tumor suppressor gene. We recently cloned a gene from this region that has greatly reduced expression in almost all lung tumor cell lines examined, in spite of being widely expressed in a variety of other tumor and nontumor cell types. We report here the sequence of this gene and show that it has significant homology to the genes encoding the ubiquitin-activating enzymes of three species, including humans. This suggests it is a second, autosomal member of this gene family in humans and may play a role in the ubiquitin conjugation pathway, which is of central importance in all eukaryotes.

AB - The chromosomal region 3p21 is thought to be the site of a lung tumor suppressor gene. We recently cloned a gene from this region that has greatly reduced expression in almost all lung tumor cell lines examined, in spite of being widely expressed in a variety of other tumor and nontumor cell types. We report here the sequence of this gene and show that it has significant homology to the genes encoding the ubiquitin-activating enzymes of three species, including humans. This suggests it is a second, autosomal member of this gene family in humans and may play a role in the ubiquitin conjugation pathway, which is of central importance in all eukaryotes.

KW - MOUSE Y-CHROMOSOME

KW - CYCLE MUTANT TS85

KW - L-CELL DEFECT

KW - MOLECULAR-CLONING

KW - ESCHERICHIA-COLI

KW - DNA-REPLICATION

KW - SEQUENCE

KW - PROTEIN

M3 - Article

SN - 0027-8424

VL - 90

SP - 6071

EP - 6075

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 13

ER -

A GENE IN THE CHROMOSOMAL REGION 3P21 WITH GREATLY REDUCED EXPRESSION IN LUNG-CANCER IS SIMILAR TO THE GENE FOR UBIQUITIN-ACTIVATING ENZYME

Abstract

Keywords

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