A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans

Nicholette D. Palmer; Caitrin W. McDonough; Pamela J. Hicks; Bong H. Roh; Maria R. Wing; S. Sandy An; Jessica M. Hester; Jessica N. Cooke; Meredith A. Bostrom; Megan E. Rudock; Matthew E. Talbert; Joshua P. Lewis; Assiamira Ferrara; Lingyi Lu; Julie T. Ziegler; Michele M. Sale; Jasmin Divers; Daniel Shriner; Adebowale Adeyemo; Charles N. Rotimi; Maggie C. Y. Ng; Carl D. Langefeld; Barry I. Freedman; Donald W. Bowden; DIAGRAM Consortium; MAGIC Investigators

doi:10.1371/journal.pone.0029202

A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans

Nicholette D. Palmer^*, Caitrin W. McDonough, Pamela J. Hicks, Bong H. Roh, Maria R. Wing, S. Sandy An, Jessica M. Hester, Jessica N. Cooke, Meredith A. Bostrom, Megan E. Rudock, Matthew E. Talbert, Joshua P. Lewis, Assiamira Ferrara, Lingyi Lu, Julie T. Ziegler, Michele M. Sale, Jasmin Divers, Daniel Shriner, Adebowale Adeyemo, Charles N. RotimiMaggie C. Y. Ng, Carl D. Langefeld, Barry I. Freedman, Donald W. Bowden, DIAGRAM Consortium, MAGIC Investigators

^*Corresponding author for this work

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Abstract

African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P

Original language	English
Article number	e29202
Number of pages	14
Journal	PLoS ONE
Volume	7
Issue number	1
DOIs	https://doi.org/10.1371/journal.pone.0029202
Publication status	Published - 4-Jan-2012

Keywords

STAGE RENAL-DISEASE
LARGE-SCALE ASSOCIATION
SUSCEPTIBILITY LOCI
INSULIN-RESISTANCE
FASTING GLUCOSE
TISSUE FACTOR
HOMEODOMAIN PROTEIN
LINKAGE ANALYSIS
COMMON VARIANTS
TCF7L2 GENE

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Palmer, N. D., McDonough, C. W., Hicks, P. J., Roh, B. H., Wing, M. R., An, S. S., Hester, J. M., Cooke, J. N., Bostrom, M. A., Rudock, M. E., Talbert, M. E., Lewis, J. P., Ferrara, A., Lu, L., Ziegler, J. T., Sale, M. M., Divers, J., Shriner, D., Adeyemo, A., ... MAGIC Investigators (2012). A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans. PLoS ONE, 7(1), Article e29202. https://doi.org/10.1371/journal.pone.0029202

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title = "A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans",

abstract = "African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P",

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author = "Palmer, {Nicholette D.} and McDonough, {Caitrin W.} and Hicks, {Pamela J.} and Roh, {Bong H.} and Wing, {Maria R.} and An, {S. Sandy} and Hester, {Jessica M.} and Cooke, {Jessica N.} and Bostrom, {Meredith A.} and Rudock, {Megan E.} and Talbert, {Matthew E.} and Lewis, {Joshua P.} and Assiamira Ferrara and Lingyi Lu and Ziegler, {Julie T.} and Sale, {Michele M.} and Jasmin Divers and Daniel Shriner and Adebowale Adeyemo and Rotimi, {Charles N.} and Ng, {Maggie C. Y.} and Langefeld, {Carl D.} and Freedman, {Barry I.} and Bowden, {Donald W.} and {DIAGRAM Consortium} and {MAGIC Investigators} and Cisca Wijmenga and {Vliet-Ostaptchouk, van}, Jana",

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Palmer, ND, McDonough, CW, Hicks, PJ, Roh, BH, Wing, MR, An, SS, Hester, JM, Cooke, JN, Bostrom, MA, Rudock, ME, Talbert, ME, Lewis, JP, Ferrara, A, Lu, L, Ziegler, JT, Sale, MM, Divers, J, Shriner, D, Adeyemo, A, Rotimi, CN, Ng, MCY, Langefeld, CD, Freedman, BI, Bowden, DW, DIAGRAM Consortium & MAGIC Investigators 2012, 'A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans', PLoS ONE, vol. 7, no. 1, e29202. https://doi.org/10.1371/journal.pone.0029202

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T1 - A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans

AU - Palmer, Nicholette D.

AU - McDonough, Caitrin W.

AU - Hicks, Pamela J.

AU - Roh, Bong H.

AU - Wing, Maria R.

AU - An, S. Sandy

AU - Hester, Jessica M.

AU - Cooke, Jessica N.

AU - Bostrom, Meredith A.

AU - Rudock, Megan E.

AU - Talbert, Matthew E.

AU - Lewis, Joshua P.

AU - Ferrara, Assiamira

AU - Lu, Lingyi

AU - Ziegler, Julie T.

AU - Sale, Michele M.

AU - Divers, Jasmin

AU - Shriner, Daniel

AU - Adeyemo, Adebowale

AU - Rotimi, Charles N.

AU - Ng, Maggie C. Y.

AU - Langefeld, Carl D.

AU - Freedman, Barry I.

AU - Bowden, Donald W.

AU - DIAGRAM Consortium

AU - MAGIC Investigators

AU - Wijmenga, Cisca

AU - Vliet-Ostaptchouk, van, Jana

PY - 2012/1/4

Y1 - 2012/1/4

N2 - African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P

AB - African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P

KW - STAGE RENAL-DISEASE

KW - LARGE-SCALE ASSOCIATION

KW - SUSCEPTIBILITY LOCI

KW - INSULIN-RESISTANCE

KW - FASTING GLUCOSE

KW - TISSUE FACTOR

KW - HOMEODOMAIN PROTEIN

KW - LINKAGE ANALYSIS

KW - COMMON VARIANTS

KW - TCF7L2 GENE

U2 - 10.1371/journal.pone.0029202

DO - 10.1371/journal.pone.0029202

M3 - Article

C2 - 22238593

SN - 1932-6203

VL - 7

JO - PLoS ONE

JF - PLoS ONE

IS - 1

M1 - e29202

ER -

A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans

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