A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

David A. van Heel; Lude Franke; Karen A. Hunt; Rhian Gwilliam; Alexandra Zhernakova; Mike Inouye; Martin C Wapenaar; Martin C. N. M. Barnardo; Graeme Bethel; Geoffrey K. T. Holmes; Con Feighery; Derek Jewell; Dermot Kelleher; Parveen Kumar; Simon Travis; Julian R. F. Walters; David S. Sanders; Peter Howdle; Jill Swift; Raymond J. Playford; William M. McLaren; M. Luisa Mearin; Chris J. Mulder; Ross McManus; Ralph McGinnis; Lon R. Cardon; Panos Deloukas; Cisca Wijmenga

doi:10.1038/ng2058

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

David A. van Heel^*
, Lude Franke
, Karen A. Hunt
, Rhian Gwilliam
, Alexandra Zhernakova
, Mike Inouye
, Martin C Wapenaar
, Martin C. N. M. Barnardo
, Graeme Bethel
, Geoffrey K. T. Holmes
, Con Feighery
, Derek Jewell
, Dermot Kelleher
, Parveen Kumar
, Simon Travis
, Julian R. F. Walters
, David S. Sanders
, Peter Howdle
, Jill Swift
, Raymond J. Playford

William M. McLaren, M. Luisa Mearin, Chris J. Mulder, Ross McManus, Ralph McGinnis, Lon R. Cardon, Panos Deloukas, Cisca Wijmenga

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

578 Citations (Scopus)

Abstract

We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding ( rs13119723; P = 2.0 x 10(-7)) was in the KIAA1109- TENR- IL2- IL21 linkage disequilibrium block. We independently confirmed association in two further collections ( strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(- 14), odds ratio 0.63), suggesting that genetic variation in this region predisposes to celiac disease.

Original language	English
Pages (from-to)	827-829
Number of pages	3
Journal	Nature Genetics
Volume	39
Issue number	7
DOIs	https://doi.org/10.1038/ng2058
Publication status	Published - Jul-2007

Keywords

INTERLEUKIN-2 GENE

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van Heel, D. A., Franke, L., Hunt, K. A., Gwilliam, R., Zhernakova, A., Inouye, M., Wapenaar, M. C., Barnardo, M. C. N. M., Bethel, G., Holmes, G. K. T., Feighery, C., Jewell, D., Kelleher, D., Kumar, P., Travis, S., Walters, J. R. F., Sanders, D. S., Howdle, P., Swift, J., ... Wijmenga, C. (2007). A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nature Genetics, 39(7), 827-829. https://doi.org/10.1038/ng2058

@article{e3f8747018b345479af66caa13e038f0,

title = "A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21",

abstract = "We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding ( rs13119723; P = 2.0 x 10(-7)) was in the KIAA1109- TENR- IL2- IL21 linkage disequilibrium block. We independently confirmed association in two further collections ( strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(- 14), odds ratio 0.63), suggesting that genetic variation in this region predisposes to celiac disease.",

keywords = "INTERLEUKIN-2 GENE",

author = "\{van Heel\}, \{David A.\} and Lude Franke and Hunt, \{Karen A.\} and Rhian Gwilliam and Alexandra Zhernakova and Mike Inouye and Wapenaar, \{Martin C\} and Barnardo, \{Martin C. N. M.\} and Graeme Bethel and Holmes, \{Geoffrey K. T.\} and Con Feighery and Derek Jewell and Dermot Kelleher and Parveen Kumar and Simon Travis and Walters, \{Julian R. F.\} and Sanders, \{David S.\} and Peter Howdle and Jill Swift and Playford, \{Raymond J.\} and McLaren, \{William M.\} and Mearin, \{M. Luisa\} and Mulder, \{Chris J.\} and Ross McManus and Ralph McGinnis and Cardon, \{Lon R.\} and Panos Deloukas and Cisca Wijmenga",

year = "2007",

month = jul,

doi = "10.1038/ng2058",

language = "English",

volume = "39",

pages = "827--829",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "7",

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van Heel, DA, Franke, L, Hunt, KA, Gwilliam, R, Zhernakova, A, Inouye, M, Wapenaar, MC, Barnardo, MCNM, Bethel, G, Holmes, GKT, Feighery, C, Jewell, D, Kelleher, D, Kumar, P, Travis, S, Walters, JRF, Sanders, DS, Howdle, P, Swift, J, Playford, RJ, McLaren, WM, Mearin, ML, Mulder, CJ, McManus, R, McGinnis, R, Cardon, LR, Deloukas, P & Wijmenga, C 2007, 'A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21', Nature Genetics, vol. 39, no. 7, pp. 827-829. https://doi.org/10.1038/ng2058

TY - JOUR

T1 - A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

AU - van Heel, David A.

AU - Franke, Lude

AU - Hunt, Karen A.

AU - Gwilliam, Rhian

AU - Zhernakova, Alexandra

AU - Inouye, Mike

AU - Wapenaar, Martin C

AU - Barnardo, Martin C. N. M.

AU - Bethel, Graeme

AU - Holmes, Geoffrey K. T.

AU - Feighery, Con

AU - Jewell, Derek

AU - Kelleher, Dermot

AU - Kumar, Parveen

AU - Travis, Simon

AU - Walters, Julian R. F.

AU - Sanders, David S.

AU - Howdle, Peter

AU - Swift, Jill

AU - Playford, Raymond J.

AU - McLaren, William M.

AU - Mearin, M. Luisa

AU - Mulder, Chris J.

AU - McManus, Ross

AU - McGinnis, Ralph

AU - Cardon, Lon R.

AU - Deloukas, Panos

AU - Wijmenga, Cisca

PY - 2007/7

Y1 - 2007/7

N2 - We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding ( rs13119723; P = 2.0 x 10(-7)) was in the KIAA1109- TENR- IL2- IL21 linkage disequilibrium block. We independently confirmed association in two further collections ( strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(- 14), odds ratio 0.63), suggesting that genetic variation in this region predisposes to celiac disease.

AB - We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding ( rs13119723; P = 2.0 x 10(-7)) was in the KIAA1109- TENR- IL2- IL21 linkage disequilibrium block. We independently confirmed association in two further collections ( strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(- 14), odds ratio 0.63), suggesting that genetic variation in this region predisposes to celiac disease.

KW - INTERLEUKIN-2 GENE

U2 - 10.1038/ng2058

DO - 10.1038/ng2058

M3 - Article

SN - 1061-4036

VL - 39

SP - 827

EP - 829

JO - Nature Genetics

JF - Nature Genetics

IS - 7

ER -

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

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