TY - GEN
T1 - A GLASS MICROFLUIDIC HANGING-DROP DEVICE FOR SENSITIVE TOXICOLOGICAL EXPERIMENTS
AU - Gier, Konstanze
AU - Mulder, Patty P.F.M.A.
AU - Mulder, Jean Paul S.H.
AU - Sauer, Ursula
AU - Verpoorte, Elisabeth
N1 - Publisher Copyright:
© 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Material choice and design of microfluidic hanging-drop (HD) devices can strongly affect the performance and outcome of toxicological screening of endocrine-disrupting chemicals (EDCs). Here, we present a glass HD platform containing a parallel well-channel design with hydrophobic perfluoropolyether (PFPE) rings around the droplet wells for high droplet stability and an enhancing effect on EDC assay performance and analysis.
AB - Material choice and design of microfluidic hanging-drop (HD) devices can strongly affect the performance and outcome of toxicological screening of endocrine-disrupting chemicals (EDCs). Here, we present a glass HD platform containing a parallel well-channel design with hydrophobic perfluoropolyether (PFPE) rings around the droplet wells for high droplet stability and an enhancing effect on EDC assay performance and analysis.
KW - 3-D cell culture
KW - droplet stability
KW - glass hanging drop
KW - hormone
KW - toxicology
UR - http://www.scopus.com/inward/record.url?scp=85136971747&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85136971747
T3 - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 323
EP - 324
BT - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
T2 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
Y2 - 10 October 2021 through 14 October 2021
ER -