A histochemical study about the involvement of rat liver cells in the uptake of heterologous immune comples from the circulation

S.M van der Laan-Klamer; J.E Atmosoerodjo-Briggs; G Harms; P.J Hoedemaeker; M.J Hardonk

doi:10.1007/BF02450483

A histochemical study about the involvement of rat liver cells in the uptake of heterologous immune comples from the circulation

S.M van der Laan-Klamer^*
, J.E Atmosoerodjo-Briggs
, G Harms
, P.J Hoedemaeker
, M.J Hardonk

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

25 Citations (Scopus)

Abstract

Intravenously injected immune complexes (ICx) composed of bovine serum albumin (BSA) and rabbit anti-BSA were taken up by the liver. Insoluble complexes, made in antibody excess, were rapidly taken up by Kupffer cells and were metabolized within 24 h.
Soluble complexes, made in antigen excess, were only partly taken up by Kupffer cells. In addition these complexes were found, taken up and metabolized by endothelial cells. Until 2 h after injection soluble complexes could also be observed along the microvilli of hepatocytes. No signs of endocytosis in hepatocytes could be observed. It is concluded, that ICx can be taken up by Kupffer cells as well as by endothelial cells. The physical state of the complexes, soluble or insoluble, determines the cell type in which uptake occurs

Original language	English
Pages (from-to)	477-482
Number of pages	6
Journal	Histochemistry
Volume	82
Issue number	5
DOIs	https://doi.org/10.1007/BF02450483
Publication status	Published - 1985

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@article{8b86742d723a44aeab0f6a09101a66b1,

title = "A histochemical study about the involvement of rat liver cells in the uptake of heterologous immune comples from the circulation",

abstract = "Intravenously injected immune complexes (ICx) composed of bovine serum albumin (BSA) and rabbit anti-BSA were taken up by the liver. Insoluble complexes, made in antibody excess, were rapidly taken up by Kupffer cells and were metabolized within 24 h. Soluble complexes, made in antigen excess, were only partly taken up by Kupffer cells. In addition these complexes were found, taken up and metabolized by endothelial cells. Until 2 h after injection soluble complexes could also be observed along the microvilli of hepatocytes. No signs of endocytosis in hepatocytes could be observed. It is concluded, that ICx can be taken up by Kupffer cells as well as by endothelial cells. The physical state of the complexes, soluble or insoluble, determines the cell type in which uptake occurs",

author = "\{van der Laan-Klamer\}, S.M and J.E Atmosoerodjo-Briggs and G Harms and P.J Hoedemaeker and M.J Hardonk",

year = "1985",

doi = "10.1007/BF02450483",

language = "English",

volume = "82",

pages = "477--482",

journal = "Histochemistry",

issn = "0301-5564",

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TY - JOUR

T1 - A histochemical study about the involvement of rat liver cells in the uptake of heterologous immune comples from the circulation

AU - van der Laan-Klamer, S.M

AU - Atmosoerodjo-Briggs, J.E

AU - Harms, G

AU - Hoedemaeker, P.J

AU - Hardonk, M.J

PY - 1985

Y1 - 1985

N2 - Intravenously injected immune complexes (ICx) composed of bovine serum albumin (BSA) and rabbit anti-BSA were taken up by the liver. Insoluble complexes, made in antibody excess, were rapidly taken up by Kupffer cells and were metabolized within 24 h. Soluble complexes, made in antigen excess, were only partly taken up by Kupffer cells. In addition these complexes were found, taken up and metabolized by endothelial cells. Until 2 h after injection soluble complexes could also be observed along the microvilli of hepatocytes. No signs of endocytosis in hepatocytes could be observed. It is concluded, that ICx can be taken up by Kupffer cells as well as by endothelial cells. The physical state of the complexes, soluble or insoluble, determines the cell type in which uptake occurs

AB - Intravenously injected immune complexes (ICx) composed of bovine serum albumin (BSA) and rabbit anti-BSA were taken up by the liver. Insoluble complexes, made in antibody excess, were rapidly taken up by Kupffer cells and were metabolized within 24 h. Soluble complexes, made in antigen excess, were only partly taken up by Kupffer cells. In addition these complexes were found, taken up and metabolized by endothelial cells. Until 2 h after injection soluble complexes could also be observed along the microvilli of hepatocytes. No signs of endocytosis in hepatocytes could be observed. It is concluded, that ICx can be taken up by Kupffer cells as well as by endothelial cells. The physical state of the complexes, soluble or insoluble, determines the cell type in which uptake occurs

U2 - 10.1007/BF02450483

DO - 10.1007/BF02450483

M3 - Article

SN - 0301-5564

VL - 82

SP - 477

EP - 482

JO - Histochemistry

JF - Histochemistry

IS - 5

ER -

A histochemical study about the involvement of rat liver cells in the uptake of heterologous immune comples from the circulation

Abstract

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