A humanized bile acid pool induced by somatic CRISPR/Cas9-mediated deletion of Cyp2c70 modulates effects of pharmacological FXR activation in mice

Jan Freark de Boer; Esther Verkade; Niels L. Mulder; Hilde D. de Vries; Nicolette Huijkman; Martijn Koehorst; Theo Boer; Justina C. Wolters; Vincent W. Bloks; Bart van de Sluis; Folkert Kuipers

A humanized bile acid pool induced by somatic CRISPR/Cas9-mediated deletion of Cyp2c70 modulates effects of pharmacological FXR activation in mice

Jan Freark de Boer, Esther Verkade, Niels L. Mulder, Hilde D. de Vries, Nicolette Huijkman, Martijn Koehorst, Theo Boer, Justina C. Wolters, Vincent W. Bloks, Bart van de Sluis, Folkert Kuipers

Research output: Contribution to journal › Meeting Abstract › Academic

Original language	English
Pages (from-to)	E25-E26
Number of pages	2
Journal	Journal of Hepatology
Volume	70
Publication status	Published - Apr-2019
Event	International Liver Congress - Vienna, Austria Duration: 10-Apr-2019 → 14-Apr-2019

Cite this

de Boer, Jan Freark ; Verkade, Esther ; Mulder, Niels L. ; de Vries, Hilde D. ; Huijkman, Nicolette ; Koehorst, Martijn ; Boer, Theo ; Wolters, Justina C. ; Bloks, Vincent W. ; van de Sluis, Bart ; Kuipers, Folkert. / A humanized bile acid pool induced by somatic CRISPR/Cas9-mediated deletion of Cyp2c70 modulates effects of pharmacological FXR activation in mice. In: Journal of Hepatology. 2019 ; Vol. 70. pp. E25-E26.

@article{1d15c0a0d9b44e7aa37ce533b3ce8b14,

title = "A humanized bile acid pool induced by somatic CRISPR/Cas9-mediated deletion of Cyp2c70 modulates effects of pharmacological FXR activation in mice",

author = "{de Boer}, {Jan Freark} and Esther Verkade and Mulder, {Niels L.} and {de Vries}, {Hilde D.} and Nicolette Huijkman and Martijn Koehorst and Theo Boer and Wolters, {Justina C.} and Bloks, {Vincent W.} and {van de Sluis}, Bart and Folkert Kuipers",

year = "2019",

month = apr,

language = "English",

volume = "70",

pages = "E25--E26",

journal = "Journal of Hepatology",

issn = "0168-8278",

publisher = "ELSEVIER SCIENCE BV",

note = "International Liver Congress ; Conference date: 10-04-2019 Through 14-04-2019",

}

A humanized bile acid pool induced by somatic CRISPR/Cas9-mediated deletion of Cyp2c70 modulates effects of pharmacological FXR activation in mice. / de Boer, Jan Freark; Verkade, Esther; Mulder, Niels L.; de Vries, Hilde D.; Huijkman, Nicolette ; Koehorst, Martijn ; Boer, Theo ; Wolters, Justina C.; Bloks, Vincent W.; van de Sluis, Bart ; Kuipers, Folkert.

In: Journal of Hepatology, Vol. 70, 04.2019, p. E25-E26.

Research output: Contribution to journal › Meeting Abstract › Academic

TY - JOUR

T1 - A humanized bile acid pool induced by somatic CRISPR/Cas9-mediated deletion of Cyp2c70 modulates effects of pharmacological FXR activation in mice

AU - de Boer, Jan Freark

AU - Verkade, Esther

AU - Mulder, Niels L.

AU - de Vries, Hilde D.

AU - Huijkman, Nicolette

AU - Koehorst, Martijn

AU - Boer, Theo

AU - Wolters, Justina C.

AU - Bloks, Vincent W.

AU - van de Sluis, Bart

AU - Kuipers, Folkert

PY - 2019/4

Y1 - 2019/4

M3 - Meeting Abstract

VL - 70

SP - E25-E26

JO - Journal of Hepatology

JF - Journal of Hepatology

SN - 0168-8278

T2 - International Liver Congress

Y2 - 10 April 2019 through 14 April 2019

ER -