TY - UNPB
T1 - A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations
AU - Million Veteran Program
AU - Nagarajan, Pavithra
AU - Winkler, Thomas W
AU - Bentley, Amy R
AU - Miller, Clint L
AU - Kraja, Aldi T
AU - Schwander, Karen
AU - Lee, Songmi
AU - Wang, Wenyi
AU - Brown, Michael R
AU - Morrison, John L
AU - Giri, Ayush
AU - O'Connell, Jeffrey R
AU - Bartz, Traci M
AU - de Las Fuentes, Lisa
AU - Gudmundsdottir, Valborg
AU - Guo, Xiuqing
AU - Harris, Sarah E
AU - Huang, Zhijie
AU - Kals, Mart
AU - Kho, Minjung
AU - Lefevre, Christophe
AU - Luan, Jian'an
AU - Lyytikäinen, Leo-Pekka
AU - Mangino, Massimo
AU - Milaneschi, Yuri
AU - Palmer, Nicholette D
AU - Rao, Varun
AU - Rauramaa, Rainer
AU - Shen, Botong
AU - Stadler, Stefan
AU - Sun, Quan
AU - Tang, Jingxian
AU - Thériault, Sébastien
AU - van der Graaf, Adriaan
AU - van der Most, Peter J
AU - Wang, Yujie
AU - Weiss, Stefan
AU - Westerman, Kenneth E
AU - Yang, Qian
AU - Yasuharu, Tabara
AU - Zhao, Wei
AU - Zhu, Wanying
AU - Altschul, Drew
AU - Ansari, Md Abu Yusuf
AU - Argoty-Pantoja, Anna D
AU - Chen, Zekai
AU - de Vries, Paul S
AU - Nolte, Ilja M
AU - Penninx, Brenda Wjh
AU - Snieder, Harold
PY - 2024/3/8
Y1 - 2024/3/8
N2 - Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for three blood pressure traits (systolic, diastolic, and pulse pressure) in 811,405 individuals from diverse population groups. We discover 22 novel gene-sleep duration interaction loci for blood pressure, mapped to genes involved in neurological, thyroidal, bone metabolism, and hematopoietic pathways. Non-overlap between short sleep (12) and long sleep (10) interactions underscores the plausibility of distinct influences of both sleep duration extremes in cardiovascular health. With several of our loci reflecting specificity towards population background or sex, our discovery sheds light on the importance of embracing granularity when addressing heterogeneity entangled in gene-environment interactions, and in therapeutic design approaches for blood pressure management.
AB - Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for three blood pressure traits (systolic, diastolic, and pulse pressure) in 811,405 individuals from diverse population groups. We discover 22 novel gene-sleep duration interaction loci for blood pressure, mapped to genes involved in neurological, thyroidal, bone metabolism, and hematopoietic pathways. Non-overlap between short sleep (12) and long sleep (10) interactions underscores the plausibility of distinct influences of both sleep duration extremes in cardiovascular health. With several of our loci reflecting specificity towards population background or sex, our discovery sheds light on the importance of embracing granularity when addressing heterogeneity entangled in gene-environment interactions, and in therapeutic design approaches for blood pressure management.
U2 - 10.1101/2024.03.07.24303870
DO - 10.1101/2024.03.07.24303870
M3 - Preprint
C2 - 38496537
T3 - medRxiv : the preprint server for health sciences
BT - A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations
PB - MedRxiv
ER -