A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations

Heming Wang; Pavithra Nagarajan; Thomas Winkler; Amy Bentley; Clint Miller; Aldi Kraja; Karen Schwander; Songmi Lee; Wenyi Wang; Michael Brown; John Morrison; Ayush Giri; Jeffrey O'Connell; Traci Bartz; Lisa de Las Fuentes; Valborg Gudmundsdottir; Xiuqing Guo; Sarah Harris; Zhijie Huang; Mart Kals; Minjung Kho; Christophe Lefevre; Jian'an Luan; Leo-Pekka Lyytikäinen; Massimo Mangino; Y Milaneschi; Nicholette Palmer; Varun Rao; Rainer Rauramaa; Botong Shen; Stefan Stadler; Quan Sun; Jingxian Tang; Sébastien Thériault; Adriaan van der Graaf; Peter van der Most; Yujie Wang; Stefan Weiss; Kenneth Westerman; Qian Yang; Tabara Yasuharu; Wei Zhao; Wanying Zhu; Drew Altschul; Md Abu Yusuf Ansari; Pramod Anugu; Anna Argoty-Pantoja; Michael Arzt; Hugues Aschard; John Attia; Lydia Bazzano; Max Breyer; Jennifer Brody; Brian Cade; Hung-Hsin Chen; Yii-Der Ida Chen; Zekai Chen; Paul de Vries; Latchezar Dimitrov; Ahn Do; Jiawen Du; Charles Dupont; Todd Edwards; Michele Evans; Tariq Faquih; Stephan Felix; Susan Fisher-Hoch; James Floyd; Mariaelisa Graff; C Charles Gu; Dongfeng Gu; Kristen Hairston; Anthony Hanley; Iris Heid; Sami Heikkinen; Heather Highland; Michelle Hood; Mika Kähönen; Carrie Karvonen-Gutierrez; Takahisa Kawaguchi; Setoh Kazuya; Kelly Tanika; Pirjo Komulainen; Daniel Levy; Henry Lin; Peter Liu; Pedro Marques-Vidal; Joseph McCormick; Hao Mei; James Meigs; Cristina Menni; Kisung Nam; Ilja Nolte; Natasha Pacheco; Lauren Petty; Hannah Polikowsky; Michael Province; Bruce Psaty; Laura Raffield; Olli Raitakari; Stephen Rich; Renata Riha; Lorenz Risch; Martin Risch; Edward Ruiz-Narvaez; Rodney Scott; Colleen Sitlani; Jennifer Smith; Tamar Sofer; Maris Teder-Laving; Uwe Völker; Peter Vollenweider; Guanchao Wang; Ko WIllems van Dijk; Otis Wilson; Rui Xia; Jie Yao; Kristin Young; Ruiyuan Zhang; Xiaofeng Zhu; Jennifer Below; Carsten Böger; David Conen; Simon Cox; Marcus Dörr; Mary Feitosa; Ervin Fox; Nora Franceschini; Sina Gharib; Vilmundur Gudnason; Sioban Harlow; Jiang He; Elizabeth Holliday; Zoltan Kutalik; Timo Lakka; Deborah Lawlor; Seunggeun Lee; Terho Lehtimäki; Changwei Li; Ching-Ti Liu; Reedik Mägi; Fumihiko Matsuda; Alanna Morrison; Brenda W J H Penninx; Patricia Peyser; Jerome Rotter; Harold Snieder; T Spector; Lynne Wagenknecht; Nicholas Wareham; Alan Zonderman; Kari North; Myriam Fornage; Adriana Hung; Alisa Manning; W Gauderman; Han Chen; Patricia Munroe; Dabeeru Rao; Diana van Heemst; Susan Redline; Raymond Noordam

doi:10.21203/rs.3.rs-4163414/v1

A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations

Heming Wang, Pavithra Nagarajan, Thomas Winkler, Amy Bentley, Clint Miller, Aldi Kraja, Karen Schwander, Songmi Lee, Wenyi Wang, Michael Brown, John Morrison, Ayush Giri, Jeffrey O'Connell, Traci Bartz, Lisa de Las Fuentes, Valborg Gudmundsdottir, Xiuqing Guo, Sarah Harris, Zhijie Huang, Mart KalsMinjung Kho, Christophe Lefevre, Jian'an Luan, Leo-Pekka Lyytikäinen, Massimo Mangino, Y Milaneschi, Nicholette Palmer, Varun Rao, Rainer Rauramaa, Botong Shen, Stefan Stadler, Quan Sun, Jingxian Tang, Sébastien Thériault, Adriaan van der Graaf, Peter van der Most, Yujie Wang, Stefan Weiss, Kenneth Westerman, Qian Yang, Tabara Yasuharu, Wei Zhao, Wanying Zhu, Drew Altschul, Md Abu Yusuf Ansari, Pramod Anugu, Anna Argoty-Pantoja, Michael Arzt, Hugues Aschard, John Attia, Lydia Bazzano, Max Breyer, Jennifer Brody, Brian Cade, Hung-Hsin Chen, Yii-Der Ida Chen, Zekai Chen, Paul de Vries, Latchezar Dimitrov, Ahn Do, Jiawen Du, Charles Dupont, Todd Edwards, Michele Evans, Tariq Faquih, Stephan Felix, Susan Fisher-Hoch, James Floyd, Mariaelisa Graff, C Charles Gu, Dongfeng Gu, Kristen Hairston, Anthony Hanley, Iris Heid, Sami Heikkinen, Heather Highland, Michelle Hood, Mika Kähönen, Carrie Karvonen-Gutierrez, Takahisa Kawaguchi, Setoh Kazuya, Kelly Tanika, Pirjo Komulainen, Daniel Levy, Henry Lin, Peter Liu, Pedro Marques-Vidal, Joseph McCormick, Hao Mei, James Meigs, Cristina Menni, Kisung Nam, Ilja Nolte, Natasha Pacheco, Lauren Petty, Hannah Polikowsky, Michael Province, Bruce Psaty, Laura Raffield, Olli Raitakari, Stephen Rich, Renata Riha, Lorenz Risch, Martin Risch, Edward Ruiz-Narvaez, Rodney Scott, Colleen Sitlani, Jennifer Smith, Tamar Sofer, Maris Teder-Laving, Uwe Völker, Peter Vollenweider, Guanchao Wang, Ko WIllems van Dijk, Otis Wilson, Rui Xia, Jie Yao, Kristin Young, Ruiyuan Zhang, Xiaofeng Zhu, Jennifer Below, Carsten Böger, David Conen, Simon Cox, Marcus Dörr, Mary Feitosa, Ervin Fox, Nora Franceschini, Sina Gharib, Vilmundur Gudnason, Sioban Harlow, Jiang He, Elizabeth Holliday, Zoltan Kutalik, Timo Lakka, Deborah Lawlor, Seunggeun Lee, Terho Lehtimäki, Changwei Li, Ching-Ti Liu, Reedik Mägi, Fumihiko Matsuda, Alanna Morrison, Brenda W J H Penninx, Patricia Peyser, Jerome Rotter, Harold Snieder, T Spector, Lynne Wagenknecht, Nicholas Wareham, Alan Zonderman, Kari North, Myriam Fornage, Adriana Hung, Alisa Manning, W Gauderman, Han Chen, Patricia Munroe, Dabeeru Rao, Diana van Heemst, Susan Redline, Raymond Noordam

Life Course Epidemiology (LCE)

Research output: Working paper › Preprint › Academic

14 Downloads (Pure)

Abstract

Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for three blood pressure traits (systolic, diastolic, and pulse pressure) in 811,405 individuals from diverse population groups. We discover 22 novel gene-sleep duration interaction loci for blood pressure, mapped to 23 genes. Investigating these genes' functional implications shed light on neurological, thyroidal, bone metabolism, and hematopoietic pathways that necessitate future investigation for blood pressure management that caters to sleep health lifestyle. Non-overlap between short sleep (12) and long sleep (10) interactions underscores the plausible nature of distinct influences of both sleep duration extremes in cardiovascular health. Several of our loci are specific towards a particular population background or sex, emphasizing the importance of addressing heterogeneity entangled in gene-environment interactions, when considering precision medicine design approaches for blood pressure management.

Original language	English
Publisher	Research Square Company
Number of pages	18
DOIs	https://doi.org/10.21203/rs.3.rs-4163414/v1
Publication status	Published - 17-Jul-2024

Publication series

Name	Research Square
Publisher	Research Square Company
ISSN (Print)	2693-5015

Access to Document

10.21203/rs.3.rs-4163414/v1Licence: CC BY

A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood PressureSubmitted manuscript, 3.64 MBLicence: CC BY

Handle.net

Persistent link

Cite this

Wang, H., Nagarajan, P., Winkler, T., Bentley, A., Miller, C., Kraja, A., Schwander, K., Lee, S., Wang, W., Brown, M., Morrison, J., Giri, A., O'Connell, J., Bartz, T., Fuentes, L. D. L., Gudmundsdottir, V., Guo, X., Harris, S., Huang, Z., ... Noordam, R. (2024). A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations. (Research Square). Research Square Company. https://doi.org/10.21203/rs.3.rs-4163414/v1

@techreport{7728d6a01a004238b730ed28f73adb4d,

title = "A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations",

abstract = "Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for three blood pressure traits (systolic, diastolic, and pulse pressure) in 811,405 individuals from diverse population groups. We discover 22 novel gene-sleep duration interaction loci for blood pressure, mapped to 23 genes. Investigating these genes' functional implications shed light on neurological, thyroidal, bone metabolism, and hematopoietic pathways that necessitate future investigation for blood pressure management that caters to sleep health lifestyle. Non-overlap between short sleep (12) and long sleep (10) interactions underscores the plausible nature of distinct influences of both sleep duration extremes in cardiovascular health. Several of our loci are specific towards a particular population background or sex, emphasizing the importance of addressing heterogeneity entangled in gene-environment interactions, when considering precision medicine design approaches for blood pressure management.",

author = "Heming Wang and Pavithra Nagarajan and Thomas Winkler and Amy Bentley and Clint Miller and Aldi Kraja and Karen Schwander and Songmi Lee and Wenyi Wang and Michael Brown and John Morrison and Ayush Giri and Jeffrey O'Connell and Traci Bartz and Fuentes, {Lisa de Las} and Valborg Gudmundsdottir and Xiuqing Guo and Sarah Harris and Zhijie Huang and Mart Kals and Minjung Kho and Christophe Lefevre and Jian'an Luan and Leo-Pekka Lyytik{\"a}inen and Massimo Mangino and Y Milaneschi and Nicholette Palmer and Varun Rao and Rainer Rauramaa and Botong Shen and Stefan Stadler and Quan Sun and Jingxian Tang and S{\'e}bastien Th{\'e}riault and {van der Graaf}, Adriaan and {van der Most}, Peter and Yujie Wang and Stefan Weiss and Kenneth Westerman and Qian Yang and Tabara Yasuharu and Wei Zhao and Wanying Zhu and Drew Altschul and Ansari, {Md Abu Yusuf} and Pramod Anugu and Anna Argoty-Pantoja and Michael Arzt and Hugues Aschard and John Attia and Lydia Bazzano and Max Breyer and Jennifer Brody and Brian Cade and Hung-Hsin Chen and Chen, {Yii-Der Ida} and Zekai Chen and {de Vries}, Paul and Latchezar Dimitrov and Ahn Do and Jiawen Du and Charles Dupont and Todd Edwards and Michele Evans and Tariq Faquih and Stephan Felix and Susan Fisher-Hoch and James Floyd and Mariaelisa Graff and Gu, {C Charles} and Dongfeng Gu and Kristen Hairston and Anthony Hanley and Iris Heid and Sami Heikkinen and Heather Highland and Michelle Hood and Mika K{\"a}h{\"o}nen and Carrie Karvonen-Gutierrez and Takahisa Kawaguchi and Setoh Kazuya and Kelly Tanika and Pirjo Komulainen and Daniel Levy and Henry Lin and Peter Liu and Pedro Marques-Vidal and Joseph McCormick and Hao Mei and James Meigs and Cristina Menni and Kisung Nam and Ilja Nolte and Natasha Pacheco and Lauren Petty and Hannah Polikowsky and Michael Province and Bruce Psaty and Laura Raffield and Olli Raitakari and Stephen Rich and Renata Riha and Lorenz Risch and Martin Risch and Edward Ruiz-Narvaez and Rodney Scott and Colleen Sitlani and Jennifer Smith and Tamar Sofer and Maris Teder-Laving and Uwe V{\"o}lker and Peter Vollenweider and Guanchao Wang and {van Dijk}, {Ko WIllems} and Otis Wilson and Rui Xia and Jie Yao and Kristin Young and Ruiyuan Zhang and Xiaofeng Zhu and Jennifer Below and Carsten B{\"o}ger and David Conen and Simon Cox and Marcus D{\"o}rr and Mary Feitosa and Ervin Fox and Nora Franceschini and Sina Gharib and Vilmundur Gudnason and Sioban Harlow and Jiang He and Elizabeth Holliday and Zoltan Kutalik and Timo Lakka and Deborah Lawlor and Seunggeun Lee and Terho Lehtim{\"a}ki and Changwei Li and Ching-Ti Liu and Reedik M{\"a}gi and Fumihiko Matsuda and Alanna Morrison and Penninx, {Brenda W J H} and Patricia Peyser and Jerome Rotter and Harold Snieder and T Spector and Lynne Wagenknecht and Nicholas Wareham and Alan Zonderman and Kari North and Myriam Fornage and Adriana Hung and Alisa Manning and W Gauderman and Han Chen and Patricia Munroe and Dabeeru Rao and {van Heemst}, Diana and Susan Redline and Raymond Noordam",

year = "2024",

month = jul,

day = "17",

doi = "10.21203/rs.3.rs-4163414/v1",

language = "English",

series = "Research Square",

publisher = "Research Square Company",

type = "WorkingPaper",

institution = "Research Square Company",

}

Wang, H, Nagarajan, P, Winkler, T, Bentley, A, Miller, C, Kraja, A, Schwander, K, Lee, S, Wang, W, Brown, M, Morrison, J, Giri, A, O'Connell, J, Bartz, T, Fuentes, LDL, Gudmundsdottir, V, Guo, X, Harris, S, Huang, Z, Kals, M, Kho, M, Lefevre, C, Luan, J, Lyytikäinen, L-P, Mangino, M, Milaneschi, Y, Palmer, N, Rao, V, Rauramaa, R, Shen, B, Stadler, S, Sun, Q, Tang, J, Thériault, S, van der Graaf, A , van der Most, P, Wang, Y, Weiss, S, Westerman, K, Yang, Q, Yasuharu, T, Zhao, W, Zhu, W, Altschul, D, Ansari, MAY, Anugu, P, Argoty-Pantoja, A, Arzt, M, Aschard, H, Attia, J, Bazzano, L, Breyer, M, Brody, J, Cade, B, Chen, H-H, Chen, Y-DI, Chen, Z, de Vries, P, Dimitrov, L, Do, A, Du, J, Dupont, C, Edwards, T, Evans, M, Faquih, T, Felix, S, Fisher-Hoch, S, Floyd, J, Graff, M, Gu, CC, Gu, D, Hairston, K, Hanley, A, Heid, I, Heikkinen, S, Highland, H, Hood, M, Kähönen, M, Karvonen-Gutierrez, C, Kawaguchi, T, Kazuya, S, Tanika, K, Komulainen, P, Levy, D, Lin, H, Liu, P, Marques-Vidal, P, McCormick, J, Mei, H, Meigs, J, Menni, C, Nam, K, Nolte, I, Pacheco, N, Petty, L, Polikowsky, H, Province, M, Psaty, B, Raffield, L, Raitakari, O, Rich, S, Riha, R, Risch, L, Risch, M, Ruiz-Narvaez, E, Scott, R, Sitlani, C, Smith, J, Sofer, T, Teder-Laving, M, Völker, U, Vollenweider, P, Wang, G, van Dijk, KWI, Wilson, O, Xia, R, Yao, J, Young, K, Zhang, R, Zhu, X, Below, J, Böger, C, Conen, D, Cox, S, Dörr, M, Feitosa, M, Fox, E, Franceschini, N, Gharib, S, Gudnason, V, Harlow, S, He, J, Holliday, E, Kutalik, Z, Lakka, T, Lawlor, D, Lee, S, Lehtimäki, T, Li, C, Liu, C-T, Mägi, R, Matsuda, F, Morrison, A, Penninx, BWJH, Peyser, P, Rotter, J, Snieder, H, Spector, T, Wagenknecht, L, Wareham, N, Zonderman, A, North, K, Fornage, M, Hung, A, Manning, A, Gauderman, W, Chen, H, Munroe, P, Rao, D, van Heemst, D, Redline, S & Noordam, R 2024 'A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations' Research Square, Research Square Company. https://doi.org/10.21203/rs.3.rs-4163414/v1

TY - UNPB

T1 - A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations

AU - Wang, Heming

AU - Nagarajan, Pavithra

AU - Winkler, Thomas

AU - Bentley, Amy

AU - Miller, Clint

AU - Kraja, Aldi

AU - Schwander, Karen

AU - Lee, Songmi

AU - Wang, Wenyi

AU - Brown, Michael

AU - Morrison, John

AU - Giri, Ayush

AU - O'Connell, Jeffrey

AU - Bartz, Traci

AU - Fuentes, Lisa de Las

AU - Gudmundsdottir, Valborg

AU - Guo, Xiuqing

AU - Harris, Sarah

AU - Huang, Zhijie

AU - Kals, Mart

AU - Kho, Minjung

AU - Lefevre, Christophe

AU - Luan, Jian'an

AU - Lyytikäinen, Leo-Pekka

AU - Mangino, Massimo

AU - Milaneschi, Y

AU - Palmer, Nicholette

AU - Rao, Varun

AU - Rauramaa, Rainer

AU - Shen, Botong

AU - Stadler, Stefan

AU - Sun, Quan

AU - Tang, Jingxian

AU - Thériault, Sébastien

AU - van der Graaf, Adriaan

AU - van der Most, Peter

AU - Wang, Yujie

AU - Weiss, Stefan

AU - Westerman, Kenneth

AU - Yang, Qian

AU - Yasuharu, Tabara

AU - Zhao, Wei

AU - Zhu, Wanying

AU - Altschul, Drew

AU - Ansari, Md Abu Yusuf

AU - Anugu, Pramod

AU - Argoty-Pantoja, Anna

AU - Arzt, Michael

AU - Aschard, Hugues

AU - Attia, John

AU - Bazzano, Lydia

AU - Breyer, Max

AU - Brody, Jennifer

AU - Cade, Brian

AU - Chen, Hung-Hsin

AU - Chen, Yii-Der Ida

AU - Chen, Zekai

AU - de Vries, Paul

AU - Dimitrov, Latchezar

AU - Do, Ahn

AU - Du, Jiawen

AU - Dupont, Charles

AU - Edwards, Todd

AU - Evans, Michele

AU - Faquih, Tariq

AU - Felix, Stephan

AU - Fisher-Hoch, Susan

AU - Floyd, James

AU - Graff, Mariaelisa

AU - Gu, C Charles

AU - Gu, Dongfeng

AU - Hairston, Kristen

AU - Hanley, Anthony

AU - Heid, Iris

AU - Heikkinen, Sami

AU - Highland, Heather

AU - Hood, Michelle

AU - Kähönen, Mika

AU - Karvonen-Gutierrez, Carrie

AU - Kawaguchi, Takahisa

AU - Kazuya, Setoh

AU - Tanika, Kelly

AU - Komulainen, Pirjo

AU - Levy, Daniel

AU - Lin, Henry

AU - Liu, Peter

AU - Marques-Vidal, Pedro

AU - McCormick, Joseph

AU - Mei, Hao

AU - Meigs, James

AU - Menni, Cristina

AU - Nam, Kisung

AU - Nolte, Ilja

AU - Pacheco, Natasha

AU - Petty, Lauren

AU - Polikowsky, Hannah

AU - Province, Michael

AU - Psaty, Bruce

AU - Raffield, Laura

AU - Raitakari, Olli

AU - Rich, Stephen

AU - Riha, Renata

AU - Risch, Lorenz

AU - Risch, Martin

AU - Ruiz-Narvaez, Edward

AU - Scott, Rodney

AU - Sitlani, Colleen

AU - Smith, Jennifer

AU - Sofer, Tamar

AU - Teder-Laving, Maris

AU - Völker, Uwe

AU - Vollenweider, Peter

AU - Wang, Guanchao

AU - van Dijk, Ko WIllems

AU - Wilson, Otis

AU - Xia, Rui

AU - Yao, Jie

AU - Young, Kristin

AU - Zhang, Ruiyuan

AU - Zhu, Xiaofeng

AU - Below, Jennifer

AU - Böger, Carsten

AU - Conen, David

AU - Cox, Simon

AU - Dörr, Marcus

AU - Feitosa, Mary

AU - Fox, Ervin

AU - Franceschini, Nora

AU - Gharib, Sina

AU - Gudnason, Vilmundur

AU - Harlow, Sioban

AU - He, Jiang

AU - Holliday, Elizabeth

AU - Kutalik, Zoltan

AU - Lakka, Timo

AU - Lawlor, Deborah

AU - Lee, Seunggeun

AU - Lehtimäki, Terho

AU - Li, Changwei

AU - Liu, Ching-Ti

AU - Mägi, Reedik

AU - Matsuda, Fumihiko

AU - Morrison, Alanna

AU - Penninx, Brenda W J H

AU - Peyser, Patricia

AU - Rotter, Jerome

AU - Snieder, Harold

AU - Spector, T

AU - Wagenknecht, Lynne

AU - Wareham, Nicholas

AU - Zonderman, Alan

AU - North, Kari

AU - Fornage, Myriam

AU - Hung, Adriana

AU - Manning, Alisa

AU - Gauderman, W

AU - Chen, Han

AU - Munroe, Patricia

AU - Rao, Dabeeru

AU - van Heemst, Diana

AU - Redline, Susan

AU - Noordam, Raymond

PY - 2024/7/17

Y1 - 2024/7/17

N2 - Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for three blood pressure traits (systolic, diastolic, and pulse pressure) in 811,405 individuals from diverse population groups. We discover 22 novel gene-sleep duration interaction loci for blood pressure, mapped to 23 genes. Investigating these genes' functional implications shed light on neurological, thyroidal, bone metabolism, and hematopoietic pathways that necessitate future investigation for blood pressure management that caters to sleep health lifestyle. Non-overlap between short sleep (12) and long sleep (10) interactions underscores the plausible nature of distinct influences of both sleep duration extremes in cardiovascular health. Several of our loci are specific towards a particular population background or sex, emphasizing the importance of addressing heterogeneity entangled in gene-environment interactions, when considering precision medicine design approaches for blood pressure management.

AB - Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for three blood pressure traits (systolic, diastolic, and pulse pressure) in 811,405 individuals from diverse population groups. We discover 22 novel gene-sleep duration interaction loci for blood pressure, mapped to 23 genes. Investigating these genes' functional implications shed light on neurological, thyroidal, bone metabolism, and hematopoietic pathways that necessitate future investigation for blood pressure management that caters to sleep health lifestyle. Non-overlap between short sleep (12) and long sleep (10) interactions underscores the plausible nature of distinct influences of both sleep duration extremes in cardiovascular health. Several of our loci are specific towards a particular population background or sex, emphasizing the importance of addressing heterogeneity entangled in gene-environment interactions, when considering precision medicine design approaches for blood pressure management.

U2 - 10.21203/rs.3.rs-4163414/v1

DO - 10.21203/rs.3.rs-4163414/v1

M3 - Preprint

C2 - 39070651

T3 - Research Square

BT - A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations

PB - Research Square Company

ER -

A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations

Abstract

Publication series

Access to Document

Handle.net

Fingerprint

Cite this