A light-actuated nanovalve derived from a channel protein

A Kocer, M Walko, W Meijberg, Bernard Feringa

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Abstract

Toward the realization of nanoscale device control, we report a molecular valve embedded in a membrane that can be opened by illumination with long-wavelength ultraviolet (366 nanometers) tight and then resealed by visible irradiation. The valve consists of a channel protein, the mechanosensitive channel of large conductance (MscL) from Escherichia coli, modified by attachment of synthetic compounds that undergo tight-induced charge separation to reversibly open and close a 3-nanometer pore. The system is compatible with a classical encapsulation system, the liposome, and external photochemical control over transport through the channel is achieved.

Original languageEnglish
Pages (from-to)755-758
Number of pages4
JournalScience
Volume309
Issue number5735
DOIs
Publication statusPublished - 29-Jul-2005

Keywords

  • MECHANOSENSITIVE ION-CHANNEL
  • ESCHERICHIA-COLI-CELLS
  • OSMOTIC DOWNSHOCK
  • LARGE-CONDUCTANCE
  • GATING MECHANISM
  • SINGLE RESIDUE
  • MSCL
  • ACTIVATION
  • MUTATIONS

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