TY - JOUR
T1 - A Magnetic Bio-Inspired Soft Carrier as a Temperature-Controlled Gastrointestinal Drug Delivery System
AU - Heunis, Christoff M.
AU - Wang, Zhuoyue
AU - de Vente, Gerko
AU - Misra, Sarthak
AU - Venkiteswaran, Venkatasubramanian Kalpathy
N1 - Funding Information:
The authors thank Dr. ir. M. Mehrpouya for his contributions and efforts with regard to the theory of shape‐memory polymers. This research has received funding from the Faculty of Engineering Technology (University of Twente) and the European Research Council (ERC) under the European Union's Horizon 2020 Research and Innovation programme (ERC Proof of Concept Grant Agreement # 966703 – project RAMSES). Opinions, interpretations, conclusions, and recommendations were those of the authors and were not necessarily endorsed by respective funding agencies.
Publisher Copyright:
© 2023 The Authors. Macromolecular Bioscience published by Wiley-VCH GmbH.
PY - 2023/3/21
Y1 - 2023/3/21
N2 - Currently, gastrointestinal bleeding in the colon wall and the small bowel is diagnosed and treated with endoscopes. However, the locations of this condition are often problematic to treat using traditional flexible and tethered tools. New studies commonly consider untethered devices for solving this problem. However, there still exists a gap in the extant literature, and more research is needed to diagnose and deliver drugs in the lower gastrointestinal tract using soft robotic carriers. This paper discusses the development of an untethered, magnetically-responsive bio-inspired soft carrier. A molding process is utilized to produce prototypes from Diisopropylidene-1,6-diphenyl-1,6-hexanediol-based Polymer with Ethylene Glycol Dimethacrylate (DiAPLEX) MP-3510 - a shape memory polymer with a low transition temperature to enable the fabrication of these carriers. The soft carrier design is validated through simulation results of deformation caused by magnetic elements embedded in the carrier in response to an external field. The thermal responsiveness of the fabricated prototype carriers is assessed ex vivo and in a phantom. The results indicate a feasible design capable of administering drugs to a target inside a phantom of a large intestine. The soft carrier introduces a method for the controlled release of drugs by utilizing the rubbery modulus of the polymer and increasing the recovery force through magnetic actuation.
AB - Currently, gastrointestinal bleeding in the colon wall and the small bowel is diagnosed and treated with endoscopes. However, the locations of this condition are often problematic to treat using traditional flexible and tethered tools. New studies commonly consider untethered devices for solving this problem. However, there still exists a gap in the extant literature, and more research is needed to diagnose and deliver drugs in the lower gastrointestinal tract using soft robotic carriers. This paper discusses the development of an untethered, magnetically-responsive bio-inspired soft carrier. A molding process is utilized to produce prototypes from Diisopropylidene-1,6-diphenyl-1,6-hexanediol-based Polymer with Ethylene Glycol Dimethacrylate (DiAPLEX) MP-3510 - a shape memory polymer with a low transition temperature to enable the fabrication of these carriers. The soft carrier design is validated through simulation results of deformation caused by magnetic elements embedded in the carrier in response to an external field. The thermal responsiveness of the fabricated prototype carriers is assessed ex vivo and in a phantom. The results indicate a feasible design capable of administering drugs to a target inside a phantom of a large intestine. The soft carrier introduces a method for the controlled release of drugs by utilizing the rubbery modulus of the polymer and increasing the recovery force through magnetic actuation.
KW - biomedical soft robots
KW - drug delivery
KW - magnetic actuation
KW - shape memory polymers
U2 - 10.1002/mabi.202200559
DO - 10.1002/mabi.202200559
M3 - Article
C2 - 36945731
AN - SCOPUS:85151721931
SN - 1616-5187
JO - Macromolecular Bioscience
JF - Macromolecular Bioscience
M1 - 2200559
ER -