A mathematical description of nerve fiber bundle trajectories and their variability in the human retina

N. M. Jansonius*, J. Nevalainen, B. Selig, L. M. Zangwill, P. A. Sample, W. M. Budde, J. B. Jonas, W. A. Lagreze, P. J. Airaksinen, R. Vonthein, L. A. Levin, J. Paetzold, U. Schiefer

*Corresponding author for this work

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    Abstract

    We developed a mathematical model wherein retinal nerve fiber trajectories can be described and the corresponding inter-subject variability analyzed. The model was based on traced nerve fiber bundle trajectories extracted from 55 fundus photographs of 55 human subjects. The model resembled the typical retinal nerve fiber layer course within 20 degrees eccentricity. Depending on the location of the visual field test point, the standard deviation of the calculated corresponding angular location at the optic nerve head circumference ranged from less than 1 degrees to 18 degrees, with an average of 8.8 degrees. (C) 2009 Elsevier Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)2157-2163
    Number of pages7
    JournalVision Research
    Volume49
    Issue number17
    DOIs
    Publication statusPublished - 28-Aug-2009

    Keywords

    • Glaucoma
    • Neuro-ophthalmology
    • Perimetry
    • Optic nerve head
    • OPTICAL COHERENCE TOMOGRAPHY
    • VISUAL-FIELD LOSS
    • LAYER THICKNESS
    • GLAUCOMA
    • HEAD
    • EYES
    • ELLIPSOMETRY
    • PHOTOGRAPHY

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