A mega-analysis of genome-wide association studies for major depressive disorder

Patrick F. Sullivan*, Mark J. Daly, Stephan Ripke, Cathryn M. Lewis, Dan-Yu Lin, Naomi R. Wray, Benjamin Neale, Douglas F. Levinson, Gerome Breen, Enda M. Byrne, Naomi R. Wray, Douglas F. Levinson, Marcella Rietschel, Witte Hoogendijk, Stephan Ripke, Patrick F. Sullivan, Steven P. Hamilton, Douglas F. Levinson, Cathryn M. Lewis, Stephan RipkeMyrna M. Weissman, Naomi R. Wray, Rene Breuer, Sven Cichon, Franziska Degenhardt, Josef Frank, Magdalena Gross, Stefan Herms, Susanne Hoefels, Wolfgang Maier, Manuel Mattheisen, Markus M. Noeethen, Marcella Rietschel, Thomas G. Schulze, Michael Steffens, Jens Treutlein, Dorret I. Boomsma, Eco J. De Geus, Witte Hoogendijk, Jouke Jan Hottenga, Tzeng Jung-Ying, Dan-Yu Lin, Christel M. Middeldorp, Willem A. Nolen, Brenda P. Penninx, Johannes H. Smit, Patrick F. Sullivan, Gerard van Grootheest, Gonneke Willemsen, Frans G. Zitman, Psychiat GWAS Consortium

*Corresponding author for this work

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Abstract

Prior genome-wide association studies (GWAS) of major depressive disorder (MDD) have met with limited success. We sought to increase statistical power to detect disease loci by conducting a GWAS mega-analysis for MDD. In the MDD discovery phase, we analyzed more than 1.2 million autosomal and X chromosome single-nucleotide polymorphisms (SNPs) in 18 759 independent and unrelated subjects of recent European ancestry (9240 MDD cases and 9519 controls). In the MDD replication phase, we evaluated 554 SNPs in independent samples (6783 MDD cases and 50 695 controls). We also conducted a cross-disorder meta-analysis using 819 autosomal SNPs with P

Original languageEnglish
Pages (from-to)497-511
Number of pages15
JournalMolecular Psychiatry
Volume18
Issue number4
DOIs
Publication statusPublished - Apr-2013

Keywords

  • genetics
  • genome-wide association study
  • major depressive disorder
  • mega-analysis
  • meta-analysis
  • CARDIOVASCULAR RISK-FACTORS
  • NATIONAL COMORBIDITY SURVEY
  • SEROTONIN TRANSPORTER GENE
  • BIPOLAR DISORDER
  • SUSCEPTIBILITY LOCI
  • PSYCHIATRIC-DISORDERS
  • MENTAL-DISORDERS
  • MOOD DISORDERS
  • TWIN REGISTRY
  • HUMAN HEIGHT

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