A mega-analysis of genome-wide association studies for major depressive disorder

Patrick F. Sullivan; Mark J. Daly; Stephan Ripke; Cathryn M. Lewis; Dan-Yu Lin; Naomi R. Wray; Benjamin Neale; Douglas F. Levinson; Gerome Breen; Enda M. Byrne; Naomi R. Wray; Douglas F. Levinson; Marcella Rietschel; Witte Hoogendijk; Stephan Ripke; Patrick F. Sullivan; Steven P. Hamilton; Douglas F. Levinson; Cathryn M. Lewis; Stephan Ripke; Myrna M. Weissman; Naomi R. Wray; Rene Breuer; Sven Cichon; Franziska Degenhardt; Josef Frank; Magdalena Gross; Stefan Herms; Susanne Hoefels; Wolfgang Maier; Manuel Mattheisen; Markus M. Noeethen; Marcella Rietschel; Thomas G. Schulze; Michael Steffens; Jens Treutlein; Dorret I. Boomsma; Eco J. De Geus; Witte Hoogendijk; Jouke Jan Hottenga; Tzeng Jung-Ying; Dan-Yu Lin; Christel M. Middeldorp; Willem A. Nolen; Brenda P. Penninx; Johannes H. Smit; Patrick F. Sullivan; Gerard van Grootheest; Gonneke Willemsen; Frans G. Zitman; Psychiat GWAS Consortium

doi:10.1038/mp.2012.21

A mega-analysis of genome-wide association studies for major depressive disorder

Patrick F. Sullivan^*, Mark J. Daly, Stephan Ripke, Cathryn M. Lewis, Dan-Yu Lin, Naomi R. Wray, Benjamin Neale, Douglas F. Levinson, Gerome Breen, Enda M. Byrne, Naomi R. Wray, Douglas F. Levinson, Marcella Rietschel, Witte Hoogendijk, Stephan Ripke, Patrick F. Sullivan, Steven P. Hamilton, Douglas F. Levinson, Cathryn M. Lewis, Stephan RipkeMyrna M. Weissman, Naomi R. Wray, Rene Breuer, Sven Cichon, Franziska Degenhardt, Josef Frank, Magdalena Gross, Stefan Herms, Susanne Hoefels, Wolfgang Maier, Manuel Mattheisen, Markus M. Noeethen, Marcella Rietschel, Thomas G. Schulze, Michael Steffens, Jens Treutlein, Dorret I. Boomsma, Eco J. De Geus, Witte Hoogendijk, Jouke Jan Hottenga, Tzeng Jung-Ying, Dan-Yu Lin, Christel M. Middeldorp, Willem A. Nolen, Brenda P. Penninx, Johannes H. Smit, Patrick F. Sullivan, Gerard van Grootheest, Gonneke Willemsen, Frans G. Zitman, Psychiat GWAS Consortium

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Prior genome-wide association studies (GWAS) of major depressive disorder (MDD) have met with limited success. We sought to increase statistical power to detect disease loci by conducting a GWAS mega-analysis for MDD. In the MDD discovery phase, we analyzed more than 1.2 million autosomal and X chromosome single-nucleotide polymorphisms (SNPs) in 18 759 independent and unrelated subjects of recent European ancestry (9240 MDD cases and 9519 controls). In the MDD replication phase, we evaluated 554 SNPs in independent samples (6783 MDD cases and 50 695 controls). We also conducted a cross-disorder meta-analysis using 819 autosomal SNPs with P

Original language	English
Pages (from-to)	497-511
Number of pages	15
Journal	Molecular Psychiatry
Volume	18
Issue number	4
DOIs	https://doi.org/10.1038/mp.2012.21
Publication status	Published - Apr-2013

Keywords

genetics
genome-wide association study
major depressive disorder
mega-analysis
meta-analysis
CARDIOVASCULAR RISK-FACTORS
NATIONAL COMORBIDITY SURVEY
SEROTONIN TRANSPORTER GENE
BIPOLAR DISORDER
SUSCEPTIBILITY LOCI
PSYCHIATRIC-DISORDERS
MENTAL-DISORDERS
MOOD DISORDERS
TWIN REGISTRY
HUMAN HEIGHT

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Sullivan, P. F., Daly, M. J., Ripke, S., Lewis, C. M., Lin, D-Y., Wray, N. R., Neale, B., Levinson, D. F., Breen, G., Byrne, E. M., Wray, N. R., Levinson, D. F., Rietschel, M., Hoogendijk, W., Ripke, S., Sullivan, P. F., Hamilton, S. P., Levinson, D. F., Lewis, C. M., ... Psychiat GWAS Consortium (2013). A mega-analysis of genome-wide association studies for major depressive disorder. Molecular Psychiatry, 18(4), 497-511. https://doi.org/10.1038/mp.2012.21

Sullivan, Patrick F. ; Daly, Mark J. ; Ripke, Stephan ; Lewis, Cathryn M. ; Lin, Dan-Yu ; Wray, Naomi R. ; Neale, Benjamin ; Levinson, Douglas F. ; Breen, Gerome ; Byrne, Enda M. ; Wray, Naomi R. ; Levinson, Douglas F. ; Rietschel, Marcella ; Hoogendijk, Witte ; Ripke, Stephan ; Sullivan, Patrick F. ; Hamilton, Steven P. ; Levinson, Douglas F. ; Lewis, Cathryn M. ; Ripke, Stephan ; Weissman, Myrna M. ; Wray, Naomi R. ; Breuer, Rene ; Cichon, Sven ; Degenhardt, Franziska ; Frank, Josef ; Gross, Magdalena ; Herms, Stefan ; Hoefels, Susanne ; Maier, Wolfgang ; Mattheisen, Manuel ; Noeethen, Markus M. ; Rietschel, Marcella ; Schulze, Thomas G. ; Steffens, Michael ; Treutlein, Jens ; Boomsma, Dorret I. ; De Geus, Eco J. ; Hoogendijk, Witte ; Hottenga, Jouke Jan ; Jung-Ying, Tzeng ; Lin, Dan-Yu ; Middeldorp, Christel M. ; Nolen, Willem A. ; Penninx, Brenda P. ; Smit, Johannes H. ; Sullivan, Patrick F. ; van Grootheest, Gerard ; Willemsen, Gonneke ; Zitman, Frans G. ; Psychiat GWAS Consortium. / A mega-analysis of genome-wide association studies for major depressive disorder. In: Molecular Psychiatry. 2013 ; Vol. 18, No. 4. pp. 497-511.

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abstract = "Prior genome-wide association studies (GWAS) of major depressive disorder (MDD) have met with limited success. We sought to increase statistical power to detect disease loci by conducting a GWAS mega-analysis for MDD. In the MDD discovery phase, we analyzed more than 1.2 million autosomal and X chromosome single-nucleotide polymorphisms (SNPs) in 18 759 independent and unrelated subjects of recent European ancestry (9240 MDD cases and 9519 controls). In the MDD replication phase, we evaluated 554 SNPs in independent samples (6783 MDD cases and 50 695 controls). We also conducted a cross-disorder meta-analysis using 819 autosomal SNPs with P",

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author = "Sullivan, {Patrick F.} and Daly, {Mark J.} and Stephan Ripke and Lewis, {Cathryn M.} and Dan-Yu Lin and Wray, {Naomi R.} and Benjamin Neale and Levinson, {Douglas F.} and Gerome Breen and Byrne, {Enda M.} and Wray, {Naomi R.} and Levinson, {Douglas F.} and Marcella Rietschel and Witte Hoogendijk and Stephan Ripke and Sullivan, {Patrick F.} and Hamilton, {Steven P.} and Levinson, {Douglas F.} and Lewis, {Cathryn M.} and Stephan Ripke and Weissman, {Myrna M.} and Wray, {Naomi R.} and Rene Breuer and Sven Cichon and Franziska Degenhardt and Josef Frank and Magdalena Gross and Stefan Herms and Susanne Hoefels and Wolfgang Maier and Manuel Mattheisen and Noeethen, {Markus M.} and Marcella Rietschel and Schulze, {Thomas G.} and Michael Steffens and Jens Treutlein and Boomsma, {Dorret I.} and {De Geus}, {Eco J.} and Witte Hoogendijk and Hottenga, {Jouke Jan} and Tzeng Jung-Ying and Dan-Yu Lin and Middeldorp, {Christel M.} and Nolen, {Willem A.} and Penninx, {Brenda P.} and Smit, {Johannes H.} and Sullivan, {Patrick F.} and {van Grootheest}, Gerard and Gonneke Willemsen and Zitman, {Frans G.} and {Psychiat GWAS Consortium}",

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doi = "10.1038/mp.2012.21",

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pages = "497--511",

journal = "Molecular Psychiatry",

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Sullivan, PF, Daly, MJ, Ripke, S, Lewis, CM, Lin, D-Y, Wray, NR, Neale, B, Levinson, DF, Breen, G, Byrne, EM, Wray, NR, Levinson, DF, Rietschel, M, Hoogendijk, W, Ripke, S, Sullivan, PF, Hamilton, SP, Levinson, DF, Lewis, CM, Ripke, S, Weissman, MM, Wray, NR, Breuer, R, Cichon, S, Degenhardt, F, Frank, J, Gross, M, Herms, S, Hoefels, S, Maier, W, Mattheisen, M, Noeethen, MM, Rietschel, M, Schulze, TG, Steffens, M, Treutlein, J, Boomsma, DI, De Geus, EJ, Hoogendijk, W, Hottenga, JJ, Jung-Ying, T, Lin, D-Y, Middeldorp, CM, Nolen, WA, Penninx, BP, Smit, JH, Sullivan, PF, van Grootheest, G, Willemsen, G, Zitman, FG & Psychiat GWAS Consortium 2013, 'A mega-analysis of genome-wide association studies for major depressive disorder', Molecular Psychiatry, vol. 18, no. 4, pp. 497-511. https://doi.org/10.1038/mp.2012.21

A mega-analysis of genome-wide association studies for major depressive disorder. / Sullivan, Patrick F.; Daly, Mark J.; Ripke, Stephan; Lewis, Cathryn M.; Lin, Dan-Yu; Wray, Naomi R.; Neale, Benjamin; Levinson, Douglas F.; Breen, Gerome; Byrne, Enda M.; Wray, Naomi R.; Levinson, Douglas F.; Rietschel, Marcella; Hoogendijk, Witte; Ripke, Stephan; Sullivan, Patrick F.; Hamilton, Steven P.; Levinson, Douglas F.; Lewis, Cathryn M.; Ripke, Stephan; Weissman, Myrna M.; Wray, Naomi R.; Breuer, Rene; Cichon, Sven; Degenhardt, Franziska; Frank, Josef; Gross, Magdalena; Herms, Stefan; Hoefels, Susanne; Maier, Wolfgang; Mattheisen, Manuel; Noeethen, Markus M.; Rietschel, Marcella; Schulze, Thomas G.; Steffens, Michael; Treutlein, Jens; Boomsma, Dorret I.; De Geus, Eco J.; Hoogendijk, Witte; Hottenga, Jouke Jan; Jung-Ying, Tzeng; Lin, Dan-Yu; Middeldorp, Christel M.; Nolen, Willem A.; Penninx, Brenda P.; Smit, Johannes H.; Sullivan, Patrick F.; van Grootheest, Gerard; Willemsen, Gonneke; Zitman, Frans G.; Psychiat GWAS Consortium.

In: Molecular Psychiatry, Vol. 18, No. 4, 04.2013, p. 497-511.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

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AU - Sullivan, Patrick F.

AU - Daly, Mark J.

AU - Ripke, Stephan

AU - Lewis, Cathryn M.

AU - Lin, Dan-Yu

AU - Wray, Naomi R.

AU - Neale, Benjamin

AU - Levinson, Douglas F.

AU - Breen, Gerome

AU - Byrne, Enda M.

AU - Wray, Naomi R.

AU - Levinson, Douglas F.

AU - Rietschel, Marcella

AU - Hoogendijk, Witte

AU - Ripke, Stephan

AU - Sullivan, Patrick F.

AU - Hamilton, Steven P.

AU - Levinson, Douglas F.

AU - Lewis, Cathryn M.

AU - Ripke, Stephan

AU - Weissman, Myrna M.

AU - Wray, Naomi R.

AU - Breuer, Rene

AU - Cichon, Sven

AU - Degenhardt, Franziska

AU - Frank, Josef

AU - Gross, Magdalena

AU - Herms, Stefan

AU - Hoefels, Susanne

AU - Maier, Wolfgang

AU - Mattheisen, Manuel

AU - Noeethen, Markus M.

AU - Rietschel, Marcella

AU - Schulze, Thomas G.

AU - Steffens, Michael

AU - Treutlein, Jens

AU - Boomsma, Dorret I.

AU - De Geus, Eco J.

AU - Hoogendijk, Witte

AU - Hottenga, Jouke Jan

AU - Jung-Ying, Tzeng

AU - Lin, Dan-Yu

AU - Middeldorp, Christel M.

AU - Nolen, Willem A.

AU - Penninx, Brenda P.

AU - Smit, Johannes H.

AU - Sullivan, Patrick F.

AU - van Grootheest, Gerard

AU - Willemsen, Gonneke

AU - Zitman, Frans G.

AU - Psychiat GWAS Consortium

PY - 2013/4

Y1 - 2013/4

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AB - Prior genome-wide association studies (GWAS) of major depressive disorder (MDD) have met with limited success. We sought to increase statistical power to detect disease loci by conducting a GWAS mega-analysis for MDD. In the MDD discovery phase, we analyzed more than 1.2 million autosomal and X chromosome single-nucleotide polymorphisms (SNPs) in 18 759 independent and unrelated subjects of recent European ancestry (9240 MDD cases and 9519 controls). In the MDD replication phase, we evaluated 554 SNPs in independent samples (6783 MDD cases and 50 695 controls). We also conducted a cross-disorder meta-analysis using 819 autosomal SNPs with P

KW - genetics

KW - genome-wide association study

KW - major depressive disorder

KW - mega-analysis

KW - meta-analysis

KW - CARDIOVASCULAR RISK-FACTORS

KW - NATIONAL COMORBIDITY SURVEY

KW - SEROTONIN TRANSPORTER GENE

KW - BIPOLAR DISORDER

KW - SUSCEPTIBILITY LOCI

KW - PSYCHIATRIC-DISORDERS

KW - MENTAL-DISORDERS

KW - MOOD DISORDERS

KW - TWIN REGISTRY

KW - HUMAN HEIGHT

U2 - 10.1038/mp.2012.21

DO - 10.1038/mp.2012.21

M3 - Article

VL - 18

SP - 497

EP - 511

JO - Molecular Psychiatry

JF - Molecular Psychiatry

SN - 1359-4184

IS - 4

ER -