A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease

Eleonora A. M. Festen; Philippe Goyette; Todd Green; Gabrielle Boucher; Claudine Beauchamp; Gosia Trynka; Patrick C. Dubois; Caroline Lagace; Pieter C. F. Stokkers; Daan W. Hommes; Donatella Barisani; Orazio Palmieri; Vito Annese; David A. van Heel; Rinse K. Weersma; Mark J. Daly; Cisca Wijmenga; John D. Rioux

doi:10.1371/journal.pgen.1001283

A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease

Eleonora A. M. Festen^*, Philippe Goyette, Todd Green, Gabrielle Boucher, Claudine Beauchamp, Gosia Trynka, Patrick C. Dubois, Caroline Lagace, Pieter C. F. Stokkers, Daan W. Hommes, Donatella Barisani, Orazio Palmieri, Vito Annese, David A. van Heel, Rinse K. Weersma, Mark J. Daly, Cisca Wijmenga, John D. Rioux

^*Corresponding author for this work

Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI)

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Crohn's disease (CD) and celiac disease (CelD) are chronic intestinal inflammatory diseases, involving genetic and environmental factors in their pathogenesis. The two diseases can co-occur within families, and studies suggest that CelD patients have a higher risk to develop CD than the general population. These observations suggest that CD and CelD may share common genetic risk loci. Two such shared loci, IL18RAP and PTPN2, have already been identified independently in these two diseases. The aim of our study was to explicitly identify shared risk loci for these diseases by combining results from genome-wide association study (GWAS) datasets of CD and CelD. Specifically, GWAS results from CelD (768 cases, 1,422 controls) and CD (3,230 cases, 4,829 controls) were combined in a meta-analysis. Nine independent regions had nominal association p-value

Original language	English
Article number	1001283
Number of pages	6
Journal	PLoS genetics
Volume	7
Issue number	1
DOIs	https://doi.org/10.1371/journal.pgen.1001283
Publication status	Published - 27-Jan-2011

Keywords

INFLAMMATORY-BOWEL-DISEASE
SUSCEPTIBILITY LOCI
ULCERATIVE-COLITIS
GENETIC-VARIANTS
MULTIPLE
IMPUTATION

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Festen, E. A. M., Goyette, P., Green, T., Boucher, G., Beauchamp, C., Trynka, G., Dubois, P. C., Lagace, C., Stokkers, P. C. F., Hommes, D. W., Barisani, D., Palmieri, O., Annese, V., van Heel, D. A., Weersma, R. K., Daly, M. J., Wijmenga, C., & Rioux, J. D. (2011). A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease. PLoS genetics, 7(1), Article 1001283. https://doi.org/10.1371/journal.pgen.1001283

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title = "A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease",

abstract = "Crohn's disease (CD) and celiac disease (CelD) are chronic intestinal inflammatory diseases, involving genetic and environmental factors in their pathogenesis. The two diseases can co-occur within families, and studies suggest that CelD patients have a higher risk to develop CD than the general population. These observations suggest that CD and CelD may share common genetic risk loci. Two such shared loci, IL18RAP and PTPN2, have already been identified independently in these two diseases. The aim of our study was to explicitly identify shared risk loci for these diseases by combining results from genome-wide association study (GWAS) datasets of CD and CelD. Specifically, GWAS results from CelD (768 cases, 1,422 controls) and CD (3,230 cases, 4,829 controls) were combined in a meta-analysis. Nine independent regions had nominal association p-value",

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author = "Festen, {Eleonora A. M.} and Philippe Goyette and Todd Green and Gabrielle Boucher and Claudine Beauchamp and Gosia Trynka and Dubois, {Patrick C.} and Caroline Lagace and Stokkers, {Pieter C. F.} and Hommes, {Daan W.} and Donatella Barisani and Orazio Palmieri and Vito Annese and {van Heel}, {David A.} and Weersma, {Rinse K.} and Daly, {Mark J.} and Cisca Wijmenga and Rioux, {John D.}",

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Festen, EAM, Goyette, P, Green, T, Boucher, G, Beauchamp, C, Trynka, G, Dubois, PC, Lagace, C, Stokkers, PCF, Hommes, DW, Barisani, D, Palmieri, O, Annese, V, van Heel, DA, Weersma, RK, Daly, MJ, Wijmenga, C & Rioux, JD 2011, 'A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease', PLoS genetics, vol. 7, no. 1, 1001283. https://doi.org/10.1371/journal.pgen.1001283

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T1 - A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease

AU - Festen, Eleonora A. M.

AU - Goyette, Philippe

AU - Green, Todd

AU - Boucher, Gabrielle

AU - Beauchamp, Claudine

AU - Trynka, Gosia

AU - Dubois, Patrick C.

AU - Lagace, Caroline

AU - Stokkers, Pieter C. F.

AU - Hommes, Daan W.

AU - Barisani, Donatella

AU - Palmieri, Orazio

AU - Annese, Vito

AU - van Heel, David A.

AU - Weersma, Rinse K.

AU - Daly, Mark J.

AU - Wijmenga, Cisca

AU - Rioux, John D.

PY - 2011/1/27

Y1 - 2011/1/27

N2 - Crohn's disease (CD) and celiac disease (CelD) are chronic intestinal inflammatory diseases, involving genetic and environmental factors in their pathogenesis. The two diseases can co-occur within families, and studies suggest that CelD patients have a higher risk to develop CD than the general population. These observations suggest that CD and CelD may share common genetic risk loci. Two such shared loci, IL18RAP and PTPN2, have already been identified independently in these two diseases. The aim of our study was to explicitly identify shared risk loci for these diseases by combining results from genome-wide association study (GWAS) datasets of CD and CelD. Specifically, GWAS results from CelD (768 cases, 1,422 controls) and CD (3,230 cases, 4,829 controls) were combined in a meta-analysis. Nine independent regions had nominal association p-value

AB - Crohn's disease (CD) and celiac disease (CelD) are chronic intestinal inflammatory diseases, involving genetic and environmental factors in their pathogenesis. The two diseases can co-occur within families, and studies suggest that CelD patients have a higher risk to develop CD than the general population. These observations suggest that CD and CelD may share common genetic risk loci. Two such shared loci, IL18RAP and PTPN2, have already been identified independently in these two diseases. The aim of our study was to explicitly identify shared risk loci for these diseases by combining results from genome-wide association study (GWAS) datasets of CD and CelD. Specifically, GWAS results from CelD (768 cases, 1,422 controls) and CD (3,230 cases, 4,829 controls) were combined in a meta-analysis. Nine independent regions had nominal association p-value

KW - INFLAMMATORY-BOWEL-DISEASE

KW - SUSCEPTIBILITY LOCI

KW - ULCERATIVE-COLITIS

KW - GENETIC-VARIANTS

KW - MULTIPLE

KW - IMPUTATION

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DO - 10.1371/journal.pgen.1001283

M3 - Article

SN - 1553-7390

VL - 7

JO - PLoS genetics

JF - PLoS genetics

IS - 1

M1 - 1001283

ER -

A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease

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Keywords

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