a-MSH enhances activity-based anorexia

Jacquelien J G Hillebrand, Martien J H Kas, Roger A H Adan

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29 Citations (Scopus)

Abstract

Activity-based anorexia (ABA) is considered an animal model of anorexia nervosa (AN). In ABA, scheduled feeding in combination with voluntary access to running wheels, results in hyperactivity, hypophagia, body weight loss and activation of the HPA axis. Since stimulation of the melanocortin (MC) system has similar effects, this system is a candidate system involved in ABA. Here it is shown that chronic alpha-MSH treatment enhances ABA by increasing running wheel activity (RWA), decreasing food intake and increasing HPA axis activation.

Original languageEnglish
Pages (from-to)1690-1696
Number of pages7
JournalPeptides
Volume26
Issue number10
DOIs
Publication statusPublished - 2005
Externally publishedYes

Keywords

  • Adrenocorticotropic Hormone
  • Animals
  • Anorexia
  • Anorexia Nervosa
  • Body Weight
  • Disease Models, Animal
  • Eating
  • Female
  • Physical Exertion
  • Rats
  • Rats, Wistar
  • Time Factors
  • alpha-MSH

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