a-MSH enhances activity-based anorexia

Jacquelien J G Hillebrand; Martien J H Kas; Roger A H Adan

doi:10.1016/j.peptides.2004.11.027

a-MSH enhances activity-based anorexia

Jacquelien J G Hillebrand, Martien J H Kas, Roger A H Adan

Research output: Contribution to journal › Article › Academic › peer-review

29 Citations (Scopus)

Abstract

Activity-based anorexia (ABA) is considered an animal model of anorexia nervosa (AN). In ABA, scheduled feeding in combination with voluntary access to running wheels, results in hyperactivity, hypophagia, body weight loss and activation of the HPA axis. Since stimulation of the melanocortin (MC) system has similar effects, this system is a candidate system involved in ABA. Here it is shown that chronic alpha-MSH treatment enhances ABA by increasing running wheel activity (RWA), decreasing food intake and increasing HPA axis activation.

Original language	English
Pages (from-to)	1690-1696
Number of pages	7
Journal	Peptides
Volume	26
Issue number	10
DOIs	https://doi.org/10.1016/j.peptides.2004.11.027
Publication status	Published - 2005
Externally published	Yes

Keywords

Adrenocorticotropic Hormone
Animals
Anorexia
Anorexia Nervosa
Body Weight
Disease Models, Animal
Eating
Female
Physical Exertion
Rats
Rats, Wistar
Time Factors
alpha-MSH

Access to Document

10.1016/j.peptides.2004.11.027

Cite this

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title = "a-MSH enhances activity-based anorexia",

abstract = "Activity-based anorexia (ABA) is considered an animal model of anorexia nervosa (AN). In ABA, scheduled feeding in combination with voluntary access to running wheels, results in hyperactivity, hypophagia, body weight loss and activation of the HPA axis. Since stimulation of the melanocortin (MC) system has similar effects, this system is a candidate system involved in ABA. Here it is shown that chronic alpha-MSH treatment enhances ABA by increasing running wheel activity (RWA), decreasing food intake and increasing HPA axis activation.",

keywords = "Adrenocorticotropic Hormone, Animals, Anorexia, Anorexia Nervosa, Body Weight, Disease Models, Animal, Eating, Female, Physical Exertion, Rats, Rats, Wistar, Time Factors, alpha-MSH",

author = "Hillebrand, {Jacquelien J G} and Kas, {Martien J H} and Adan, {Roger A H}",

year = "2005",

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language = "English",

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pages = "1690--1696",

journal = "Peptides",

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T1 - a-MSH enhances activity-based anorexia

AU - Hillebrand, Jacquelien J G

AU - Kas, Martien J H

AU - Adan, Roger A H

PY - 2005

Y1 - 2005

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AB - Activity-based anorexia (ABA) is considered an animal model of anorexia nervosa (AN). In ABA, scheduled feeding in combination with voluntary access to running wheels, results in hyperactivity, hypophagia, body weight loss and activation of the HPA axis. Since stimulation of the melanocortin (MC) system has similar effects, this system is a candidate system involved in ABA. Here it is shown that chronic alpha-MSH treatment enhances ABA by increasing running wheel activity (RWA), decreasing food intake and increasing HPA axis activation.

KW - Adrenocorticotropic Hormone

KW - Animals

KW - Anorexia

KW - Anorexia Nervosa

KW - Body Weight

KW - Disease Models, Animal

KW - Eating

KW - Female

KW - Physical Exertion

KW - Rats

KW - Rats, Wistar

KW - Time Factors

KW - alpha-MSH

U2 - 10.1016/j.peptides.2004.11.027

DO - 10.1016/j.peptides.2004.11.027

M3 - Article

C2 - 15964664

VL - 26

SP - 1690

EP - 1696

JO - Peptides

JF - Peptides

SN - 0196-9781

IS - 10

ER -