A multi-module, microfluidic gastrointestinal tract for testing food and drugs

Pim de Haan, Milou J.C. Santbergen, Meike van der Zande, Hans Bouwmeester, Michel W.F. Nielen, Elisabeth Verpoorte

Research output: Contribution to conferenceAbstractAcademic

Abstract

This work describes our efforts to date to realize a miniaturized gastrointestinal (GI) tract total analysis system (gut-μTAS) for nutrients or drugs upon ingestion. A multi-module flow system is being developed that seeks to combine all processes of the GI tract, including enzymatic digestion, absorption, and metabolism together with online mass spectrometry analysis. When exposing cells to digested materials (chyme), we found that the cells tolerate up to ~15% of chyme in the cellular matrix. Finally, we monitored the absorption of model drug, verapamil, in the gut-on-a-chip device by online mass spectrometry (MS) analysis.
Original languageEnglish
Pages378-379
Publication statusPublished - 26-Oct-2019
Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences - Basel, Basel, Switzerland
Duration: 26-Oct-201931-Oct-2019
Conference number: 23
http://microtas2019.org

Conference

Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences
Abbreviated titleµTAS 2019
CountrySwitzerland
CityBasel
Period26/10/201931/10/2019
Internet address

Keywords

  • Gut-on-a-chip, Digestion, Mass spectrometry, Oral bioavailability

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