A multi-module, microfluidic gastrointestinal tract for testing food and drugs

Pim de Haan; Milou J.C. Santbergen; Meike van der Zande; Hans Bouwmeester; Michel W.F. Nielen; Elisabeth Verpoorte

A multi-module, microfluidic gastrointestinal tract for testing food and drugs

Pim de Haan, Milou J.C. Santbergen, Meike van der Zande, Hans Bouwmeester, Michel W.F. Nielen, Elisabeth Verpoorte

Research output: Contribution to conference › Abstract › Academic

Abstract

This work describes our efforts to date to realize a miniaturized gastrointestinal (GI) tract total analysis system (gut-μTAS) for nutrients or drugs upon ingestion. A multi-module flow system is being developed that seeks to combine all processes of the GI tract, including enzymatic digestion, absorption, and metabolism together with online mass spectrometry analysis. When exposing cells to digested materials (chyme), we found that the cells tolerate up to ~15% of chyme in the cellular matrix. Finally, we monitored the absorption of model drug, verapamil, in the gut-on-a-chip device by online mass spectrometry (MS) analysis.

Original language	English
Pages	378-379
Publication status	Published - 26-Oct-2019
Event	23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences - Basel, Basel, Switzerland Duration: 26-Oct-2019 → 31-Oct-2019 Conference number: 23 http://microtas2019.org

Conference

Conference	23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences
Abbreviated title	µTAS 2019
Country	Switzerland
City	Basel
Period	26/10/2019 → 31/10/2019
Internet address	http://microtas2019.org

Keywords

Gut-on-a-chip, Digestion, Mass spectrometry, Oral bioavailability

Cite this

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title = "A multi-module, microfluidic gastrointestinal tract for testing food and drugs",

abstract = "This work describes our efforts to date to realize a miniaturized gastrointestinal (GI) tract total analysis system (gut-μTAS) for nutrients or drugs upon ingestion. A multi-module flow system is being developed that seeks to combine all processes of the GI tract, including enzymatic digestion, absorption, and metabolism together with online mass spectrometry analysis. When exposing cells to digested materials (chyme), we found that the cells tolerate up to ~15% of chyme in the cellular matrix. Finally, we monitored the absorption of model drug, verapamil, in the gut-on-a-chip device by online mass spectrometry (MS) analysis.",

keywords = "Gut-on-a-chip, Digestion, Mass spectrometry, Oral bioavailability",

author = "{de Haan}, Pim and Santbergen, {Milou J.C.} and {van der Zande}, Meike and Hans Bouwmeester and Nielen, {Michel W.F.} and Elisabeth Verpoorte",

year = "2019",

month = oct,

day = "26",

language = "English",

pages = "378--379",

note = "23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019 ; Conference date: 26-10-2019 Through 31-10-2019",

url = "http://microtas2019.org",

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A multi-module, microfluidic gastrointestinal tract for testing food and drugs. / de Haan, Pim; Santbergen, Milou J.C.; van der Zande, Meike; Bouwmeester, Hans; Nielen, Michel W.F.; Verpoorte, Elisabeth.

2019. 378-379 Abstract from 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, Basel, Switzerland.

Research output: Contribution to conference › Abstract › Academic

TY - CONF

T1 - A multi-module, microfluidic gastrointestinal tract for testing food and drugs

AU - de Haan, Pim

AU - Santbergen, Milou J.C.

AU - van der Zande, Meike

AU - Bouwmeester, Hans

AU - Nielen, Michel W.F.

AU - Verpoorte, Elisabeth

N1 - Conference code: 23

PY - 2019/10/26

Y1 - 2019/10/26

N2 - This work describes our efforts to date to realize a miniaturized gastrointestinal (GI) tract total analysis system (gut-μTAS) for nutrients or drugs upon ingestion. A multi-module flow system is being developed that seeks to combine all processes of the GI tract, including enzymatic digestion, absorption, and metabolism together with online mass spectrometry analysis. When exposing cells to digested materials (chyme), we found that the cells tolerate up to ~15% of chyme in the cellular matrix. Finally, we monitored the absorption of model drug, verapamil, in the gut-on-a-chip device by online mass spectrometry (MS) analysis.

AB - This work describes our efforts to date to realize a miniaturized gastrointestinal (GI) tract total analysis system (gut-μTAS) for nutrients or drugs upon ingestion. A multi-module flow system is being developed that seeks to combine all processes of the GI tract, including enzymatic digestion, absorption, and metabolism together with online mass spectrometry analysis. When exposing cells to digested materials (chyme), we found that the cells tolerate up to ~15% of chyme in the cellular matrix. Finally, we monitored the absorption of model drug, verapamil, in the gut-on-a-chip device by online mass spectrometry (MS) analysis.

KW - Gut-on-a-chip, Digestion, Mass spectrometry, Oral bioavailability

M3 - Abstract

SP - 378

EP - 379

T2 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences

Y2 - 26 October 2019 through 31 October 2019

ER -