A multi-national comparison of antipsychotic drug use in children and adolescents, 2005-2012

Luuk J Kalverdijk, Christian J Bachmann, Lise Aagaard, Mehmet Burcu, Gerd Glaeske, Falk Hoffmann, Irene Petersen, Catharina C M Schuiling-Veninga, Linda P Wijlaars, Julie M Zito

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Abstract

Over the last decades, an increase in antipsychotic (AP) prescribing and a shift from first-generation antipsychotics (FGA) to second-generation antipsychotics (SGA) among youth have been reported. However, most AP prescriptions for youth are off-label, and there are worrying long-term safety data in youth. The objective of this study was to assess multinational trends in AP use among children and adolescents. A repeated cross-sectional design was applied to cohorts from varied sources from Denmark, Germany, the Netherlands, the United Kingdom (UK) and the United States (US) for calendar years 2005/2006-2012. The annual prevalence of AP use was assessed, stratified by age group, sex and subclass (FGA/SGA). The prevalence of AP use increased from 0.78 to 1.03% in the Netherlands' data, from 0.26 to 0.48% in the Danish cohort, from 0.23 to 0.32% in the German cohort, and from 0.1 to 0.14% in the UK cohort. In the US cohort, AP use decreased from 0.94 to 0.79%. In the US cohort, nearly all ATP dispensings were for SGA, while among the European cohorts the proportion of SGA dispensings grew to nearly 75% of all AP dispensings. With the exception of the Netherlands, AP use prevalence was highest in 15-19 year-olds. So, from 2005/6 to 2012, AP use prevalence increased in all youth cohorts from European countries and decreased in the US cohort. SGA were favoured in all countries' cohorts.

Original languageEnglish
Article number55
Number of pages9
JournalChild and Adolescent Psychiatry Mental Health
Volume11
DOIs
Publication statusPublished - 11-Oct-2017

Keywords

  • Adolescents
  • Children
  • Antipsychotic drugs
  • Atypical
  • Denmark
  • Germany
  • Netherlands
  • UK
  • USA
  • Pharmacoepidemiology
  • AUTISM SPECTRUM DISORDERS
  • 2ND-GENERATION ANTIPSYCHOTICS
  • UNITED-STATES
  • PRIMARY-CARE
  • TARDIVE-DYSKINESIA
  • INSURED CHILDREN
  • PUBLIC-ATTITUDES
  • MEDICATIONS
  • BEHAVIOR
  • RISK

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