A multicentre study of air pollution exposure and childhood asthma prevalence: the ESCAPE project

Anna Moelter*, Angela Simpson, Dietrich Berdel, Bert Brunekreef, Adnan Custovic, Josef Cyrys, Johan de Jongste, Frank de Vocht, Elaine Fuertes, Ulrike Gehring, Olena Gruzieva, Joachim Heinrich, Gerard Hoek, Barbara Hoffmann, Claudia Kluemper, Michal Korek, Thomas A. J. Kuhlbusch, Sarah Lindley, Dirkje Postma, Christina TischerAlet Wijga, Goran Pershagen, Raymond Agius

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

93 Citations (Scopus)

Abstract

The aim of this study was to determine the effect of six traffic-related air pollution metrics (nitrogen dioxide, nitrogen oxides, particulate matter with an aerodynamic diameter

Land-use regression models were developed for each study area and used to estimate outdoor air pollution exposure at the home address of each child. Information on asthma and current wheeze prevalence at the ages of 4-5 and 8-10 years was collected using validated questionnaires. Multiple logistic regression was used to analyse the association between pollutant exposure and asthma within each cohort. Random-effects meta-analyses were used to combine effect estimates from individual cohorts.

The meta-analyses showed no significant association between asthma prevalence and air pollution exposure (e.g. adjusted OR (95%CI) for asthma at age 8-10 years and exposure at the birth address (n=10377): 1.10 (0.81-1.49) per 10 mu g.m(-3) nitrogen dioxide; 0.88 (0.63-1.24) per 10 mu g.m(-3) PM10; 1.23 (0.78-1.95) per 5 mu g.m(-3) PM2.5). This result was consistently found in initial crude models, adjusted models and further sensitivity analyses.

This study found no significant association between air pollution exposure and childhood asthma prevalence in five European birth cohorts.

Original languageEnglish
Pages (from-to)610-624
Number of pages15
JournalEuropean Respiratory Journal
Volume45
Issue number3
DOIs
Publication statusPublished - Mar-2015

Keywords

  • USE REGRESSION-MODELS
  • CHILDRENS RESPIRATORY SYMPTOMS
  • LONG-TERM EXPOSURE
  • BIRTH COHORT
  • NITROGEN-DIOXIDE
  • PARTICULATE MATTER
  • PM2.5 ABSORBENCY
  • LUNG-FUNCTION
  • NO2
  • AREAS

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