A multicomponent tetrazolo indole synthesis

Xiaofang Lei; Panagiota Lampiri; Pravin Patil; Giasemi Angeli; Constantinos G Neochoritis; Alexander Dömling

doi:10.1039/d1cc02384e

A multicomponent tetrazolo indole synthesis

Xiaofang Lei, Panagiota Lampiri, Pravin Patil, Giasemi Angeli, Constantinos G Neochoritis^*, Alexander Dömling^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

5 Citations (Scopus)

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Abstract

The ubiquitous presence of the indole fragment in natural products and drugs asks for ever novel syntheses. We report an unprecedented mild, two-step synthesis of 2-tetrazolo substituted indoles based on the Ugi-tetrazole reaction combined with an acidic ring closure. A gram-scale synthesis, a bioactive compound and further transformations were performed.

Original language	English
Pages (from-to)	6652-6655
Number of pages	4
Journal	Chemical communications (Cambridge, England)
Volume	57
Issue number	54
DOIs	https://doi.org/10.1039/d1cc02384e
Publication status	Published - 6-Jul-2021

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10.1039/d1cc02384eLicence: CC BY-NC

A multicomponent tetrazolo indole synthesisFinal publisher's version, 3.47 MBLicence: CC BY-NC

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CCDC 2077271: Experimental Crystal Structure Determination
Lei, X. (Contributor), Lampiri, P. (Contributor), Patil, P. (Contributor), Angeli, G. (Contributor), Neochoritis, C. G. (Contributor) & Dömling, A. (Contributor), The Cambridge Structural Database, 13-Apr-2021
DOI: 10.5517/ccdc.csd.cc27qkr9
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title = "A multicomponent tetrazolo indole synthesis",

abstract = "The ubiquitous presence of the indole fragment in natural products and drugs asks for ever novel syntheses. We report an unprecedented mild, two-step synthesis of 2-tetrazolo substituted indoles based on the Ugi-tetrazole reaction combined with an acidic ring closure. A gram-scale synthesis, a bioactive compound and further transformations were performed.",

author = "Xiaofang Lei and Panagiota Lampiri and Pravin Patil and Giasemi Angeli and Neochoritis, {Constantinos G} and Alexander D{\"o}mling",

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T1 - A multicomponent tetrazolo indole synthesis

AU - Lei, Xiaofang

AU - Lampiri, Panagiota

AU - Patil, Pravin

AU - Angeli, Giasemi

AU - Neochoritis, Constantinos G

AU - Dömling, Alexander

PY - 2021/7/6

Y1 - 2021/7/6

N2 - The ubiquitous presence of the indole fragment in natural products and drugs asks for ever novel syntheses. We report an unprecedented mild, two-step synthesis of 2-tetrazolo substituted indoles based on the Ugi-tetrazole reaction combined with an acidic ring closure. A gram-scale synthesis, a bioactive compound and further transformations were performed.

AB - The ubiquitous presence of the indole fragment in natural products and drugs asks for ever novel syntheses. We report an unprecedented mild, two-step synthesis of 2-tetrazolo substituted indoles based on the Ugi-tetrazole reaction combined with an acidic ring closure. A gram-scale synthesis, a bioactive compound and further transformations were performed.

U2 - 10.1039/d1cc02384e

DO - 10.1039/d1cc02384e

M3 - Article

C2 - 34128009

SN - 1359-7345

VL - 57

SP - 6652

EP - 6655

JO - Chemical Communications (Cambridge, United Kingdom)

JF - Chemical Communications (Cambridge, United Kingdom)

IS - 54

ER -

A multicomponent tetrazolo indole synthesis

Abstract

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Datasets

CCDC 2077271: Experimental Crystal Structure Determination

Cite this