A multicomponent tetrazolo indole synthesis

Xiaofang Lei, Panagiota Lampiri, Pravin Patil, Giasemi Angeli, Constantinos G Neochoritis*, Alexander Dömling*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)
38 Downloads (Pure)


The ubiquitous presence of the indole fragment in natural products and drugs asks for ever novel syntheses. We report an unprecedented mild, two-step synthesis of 2-tetrazolo substituted indoles based on the Ugi-tetrazole reaction combined with an acidic ring closure. A gram-scale synthesis, a bioactive compound and further transformations were performed.

Original languageEnglish
Pages (from-to)6652-6655
Number of pages4
JournalChemical communications (Cambridge, England)
Issue number54
Publication statusPublished - 6-Jul-2021

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