TY - JOUR
T1 - A national study to assess outcomes of definitive chemoradiation regimens in proximal esophageal cancer
AU - de Vos-Geelen, Judith
AU - Hoebers, Frank J. P.
AU - Geurts, Sandra M. E.
AU - Hoeben, Ann
AU - de Greef, Bianca T. A.
AU - Voncken, Francine E. M.
AU - Bogers, J. (Hans) A.
AU - Braam, Petra M.
AU - Muijs, C. (Kristel) T.
AU - de Jong, Martin A.
AU - Kasperts, Nicolien
AU - Rozema, Tom
AU - Jeene, Paul M.
AU - Blom, Gerrit J.
AU - van Dieren, Jolanda M.
AU - Hulshof, Maarten C. C. M.
AU - van Laarhoven, Hanneke W. M.
AU - Grabsch, Heike
AU - Lemmens, Valery E. P. P.
AU - Tjan-Heijnen, Vivianne C. G.
AU - Nieuwenhuijzen, Grard A. P.
PY - 2020/8/2
Y1 - 2020/8/2
N2 - Background: Proximal esophageal cancer (EC) is commonly treated with definitive chemoradiation (CRT). The radiation dose and type of chemotherapy backbone are still under debate. The objective of this study was to compare the treatment outcomes of contemporary CRT regimens. Material and Methods: In this retrospective observational cohort study, we included patients with locally advanced squamous cell cancer of the proximal esophagus, from 11 centers in the Netherlands, treated with definitive CRT between 2004 and 2014. Each center had a preferential CRT regimen, based on cisplatin (Cis) or carboplatin-paclitaxel (CP) combined with low (50.4 Gy) dose radiotherapy (RT). Differences in overall survival (OS) between CRT regimens were assessed using a fully adjusted Cox proportional hazards and propensity score (PS) weighted model. Safety profiles were compared using a multilevel logistic regression model. Results: Two hundred patients were included. Fifty-four, 39, 95, and 12 patients were treated with Cis-low-dose RT, Cis-high-dose RT, CP-low-dose RT, and CP-high-dose RT, respectively. Median follow-up was 62.6 months (95% CI: 47.9-77.2 months). Median OS (21.9 months; 95% CI: 16.9-27.0 months) was comparable between treatment groups (logrank p = .88), confirmed in the fully adjusted and PS weighted model (p > .05). Grades 3-5 acute adverse events were less frequent in patients treated with CP-low-dose RT versus Cis-high-dose RT (OR 3.78; 95% CI: 1.31-10.87; p = .01). The occurrence of grades 3-5 late toxicities was not different between treatment groups. Conclusion: Our study was unable to demonstrate a difference in OS between the CRT regimens, probably related to the relatively small sample size. Based on the superior safety profile, carboplatin and paclitaxel-based CRT regimens are preferred in patients with locally advanced proximal EC.
AB - Background: Proximal esophageal cancer (EC) is commonly treated with definitive chemoradiation (CRT). The radiation dose and type of chemotherapy backbone are still under debate. The objective of this study was to compare the treatment outcomes of contemporary CRT regimens. Material and Methods: In this retrospective observational cohort study, we included patients with locally advanced squamous cell cancer of the proximal esophagus, from 11 centers in the Netherlands, treated with definitive CRT between 2004 and 2014. Each center had a preferential CRT regimen, based on cisplatin (Cis) or carboplatin-paclitaxel (CP) combined with low (50.4 Gy) dose radiotherapy (RT). Differences in overall survival (OS) between CRT regimens were assessed using a fully adjusted Cox proportional hazards and propensity score (PS) weighted model. Safety profiles were compared using a multilevel logistic regression model. Results: Two hundred patients were included. Fifty-four, 39, 95, and 12 patients were treated with Cis-low-dose RT, Cis-high-dose RT, CP-low-dose RT, and CP-high-dose RT, respectively. Median follow-up was 62.6 months (95% CI: 47.9-77.2 months). Median OS (21.9 months; 95% CI: 16.9-27.0 months) was comparable between treatment groups (logrank p = .88), confirmed in the fully adjusted and PS weighted model (p > .05). Grades 3-5 acute adverse events were less frequent in patients treated with CP-low-dose RT versus Cis-high-dose RT (OR 3.78; 95% CI: 1.31-10.87; p = .01). The occurrence of grades 3-5 late toxicities was not different between treatment groups. Conclusion: Our study was unable to demonstrate a difference in OS between the CRT regimens, probably related to the relatively small sample size. Based on the superior safety profile, carboplatin and paclitaxel-based CRT regimens are preferred in patients with locally advanced proximal EC.
KW - STANDARD-DOSE RADIATION
KW - PHASE-III TRIAL
KW - SQUAMOUS-CELL CARCINOMA
KW - CHEMORADIOTHERAPY
KW - RADIOTHERAPY
KW - CISPLATIN
KW - THERAPY
KW - SURGERY
KW - CHEMOTHERAPY
KW - MULTICENTER
U2 - 10.1080/0284186X.2020.1753889
DO - 10.1080/0284186X.2020.1753889
M3 - Article
SN - 0284-186X
VL - 59
SP - 895
EP - 903
JO - ACTA ONCOLOGICA
JF - ACTA ONCOLOGICA
IS - 8
ER -