A neurodegenerative tragedy. Pathogenesis and treatment of amyotrophic lateral sclerosis

K.H. Bongaerts, A.J.M. Loonen

    Research output: Contribution to journalArticleAcademicpeer-review

    Abstract

    Amyotrophic lateral sclerosis(ALS) is a chronic progressive neurological disorder characterised by degeneration of upper and lower motor neurons. Patients suffer from paresis and atrophy of the affected muscle groups and changes of myotactic reflexes. They usually pass away within 3-5 years, although some may live for over 10 years. An unequivocal pathogenetic mechanism has not yet been identified. Putative causes are found in a dysfunction of the glutamate transport system and/or a in change of the activity of the Cu/Zn superoxide dismutase. At present only rilusole is available to treat ALS. For the time being, a symptomatic treatment is the only therapy we have to offer in addition. Promising are the effects of certain neurotrophic factors in mice.
    Translated title of the contributionA neurodegenerative tragedy. Pathogenesis and treatment of amyotrophic lateral sclerosis
    Original languageDutch
    Pages (from-to)928-934
    Number of pages7
    JournalPharmaceutisch Weekblad
    Volume136
    Issue number26
    Publication statusPublished - 29-Jun-2001

    Keywords

    • copper zinc superoxide dismutase
    • glutamate transporter
    • riluzole
    • amyotrophic lateral sclerosis
    • article
    • degenerative disease
    • disease course
    • human
    • muscle atrophy
    • myotatic reflex
    • paresis
    • pathogenesis

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