A novel method to highly versatile monomeric PNA building blocks by multi component reactions

Alexander Dömling, Kai-Zu Chi, Mathieux Barrère

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32 Citations (Scopus)


A novel approach to monomeric PNA building blocks by a solution phase Ugi multi component reaction (MCR) is described. The reaction is easily performed in 96 well plates. The products precipitate from the reaction solution and are thus obtained in high yields and purity. Those products are not amenable by another multi step synthesis in such a diversity.
Original languageEnglish
Pages (from-to)2871-2874
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number19
Publication statusPublished - 4-Oct-1999


  • Combinatorial chemistry
  • MCR
  • PNA
  • Ugi reaction
  • nucleic acid precursor
  • peptide nucleic acid
  • article
  • chemical reaction
  • drug purity
  • drug synthesis
  • nucleic acid probe
  • racemic mixture
  • stereochemistry

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