A novel peptide-based vaccine candidate with protective efficacy against influenza A in a mouse model

José Herrera-Rodriguez, Tjarko Meijerhof, Hubert G Niesters, Grete Stjernholm, Arnt-Ove Hovden, Birger Sørensen, Mats Ökvist, Maja A Sommerfelt, Anke Huckriede*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Abstract

Current influenza vaccines mainly induce antibody responses to the variable hemagglutinin proteins of the virus strains included in the vaccine. Instead, a broadly protective influenza vaccine should aim at inducing antibody and/or cell -mediated immunity against conserved viral proteins. Vacc-FLU is a peptide based vaccine combining conserved B and T cell epitopes. Peptide selection was done using a proprietary peptide design platform technology focusing on responses to human leukocyte antigen (HLA)-restricted epitopes. Immunization of wild -type mice and mice transgenic for HLA-A2.1 with the peptide mix successfully induced both humoral and cell mediated immune responses. Partial protection from severe weight loss upon challenge was observed in both mouse strains but was stronger and observed at lower vaccine doses in transgenic mice. Our results show that the Vacc-FLU peptide mix is capable of inducing IFNy-producing T cells and antibody-producing B cells which can protect from severe disease symptoms upon infection.

Original languageEnglish
Pages (from-to)21-28
Number of pages8
JournalVirology
Volume515
Early online date7-Dec-2017
DOIs
Publication statusPublished - Feb-2018

Keywords

  • Influenza
  • Universal vaccine
  • Peptides
  • Cell mediated immunity
  • Humoral immunity
  • T-CELL EPITOPES
  • VIRUS
  • RESPONSES
  • IMMUNITY
  • SAFETY
  • TRIAL

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