A novel PPP2R2A::PRKD1 fusion in a cribriform adenocarcinoma of salivary gland

Vincent D de Jager; Sebastiaan A H J de Visscher; Ed Schuuring; Jan J Doff; Léon C van Kempen

doi:10.1002/gcc.23122

A novel PPP2R2A::PRKD1 fusion in a cribriform adenocarcinoma of salivary gland

Vincent D de Jager, Sebastiaan A H J de Visscher, Ed Schuuring, Jan J Doff, Léon C van Kempen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Cribriform adenocarcinoma of salivary gland (CASG) is a rare, salivary gland tumor. In this report, we describe a case of CASG harboring a novel PPP2R2A::PRKD1 fusion. A 58-year-old female presented with an intraoral mass adjacent to the lower left third molar region. Morphological features at histological examination, immunohistochemical staining (p63+, p40-), and tumor location were indicative of CASG. However, due to the potential focal presence of a biphasic component within the tumor, RNA sequencing was performed to confirm the diagnosis. The subsequently found novel PPP2R2A::PRKD1 fusion adds to the rapidly evolving molecular landscape of salivary gland tumors. Additionally, we report that CASG may show some entrapment of pre-existent salivary gland ducts, which may be misinterpreted as tumor cells with myoepithelial differentiation.

Original language	English
Pages (from-to)	297-300
Number of pages	4
Journal	Genes Chromosomes & Cancer
Volume	62
Issue number	5
DOIs	https://doi.org/10.1002/gcc.23122
Publication status	Published - May-2023

Keywords

Female
Humans
Middle Aged
Adenocarcinoma/pathology
Salivary Glands
Transcription Factors
Salivary Gland Neoplasms/pathology
Biomarkers, Tumor/genetics
Protein Phosphatase 2/genetics

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A novel PPP2R2A::PRKD1 fusion in a cribriform adenocarcinoma of salivary glandFinal publisher's version, 1.86 MBLicence: CC BY-NC-ND

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title = "A novel PPP2R2A::PRKD1 fusion in a cribriform adenocarcinoma of salivary gland",

abstract = "Cribriform adenocarcinoma of salivary gland (CASG) is a rare, salivary gland tumor. In this report, we describe a case of CASG harboring a novel PPP2R2A::PRKD1 fusion. A 58-year-old female presented with an intraoral mass adjacent to the lower left third molar region. Morphological features at histological examination, immunohistochemical staining (p63+, p40-), and tumor location were indicative of CASG. However, due to the potential focal presence of a biphasic component within the tumor, RNA sequencing was performed to confirm the diagnosis. The subsequently found novel PPP2R2A::PRKD1 fusion adds to the rapidly evolving molecular landscape of salivary gland tumors. Additionally, we report that CASG may show some entrapment of pre-existent salivary gland ducts, which may be misinterpreted as tumor cells with myoepithelial differentiation.",

keywords = "Female, Humans, Middle Aged, Adenocarcinoma/pathology, Salivary Glands, Transcription Factors, Salivary Gland Neoplasms/pathology, Biomarkers, Tumor/genetics, Protein Phosphatase 2/genetics",

author = "{de Jager}, {Vincent D} and {de Visscher}, {Sebastiaan A H J} and Ed Schuuring and Doff, {Jan J} and {van Kempen}, {L{\'e}on C}",

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year = "2023",

month = may,

doi = "10.1002/gcc.23122",

language = "English",

volume = "62",

pages = "297--300",

journal = "Genes Chromosomes & Cancer",

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T1 - A novel PPP2R2A::PRKD1 fusion in a cribriform adenocarcinoma of salivary gland

AU - de Jager, Vincent D

AU - de Visscher, Sebastiaan A H J

AU - Schuuring, Ed

AU - Doff, Jan J

AU - van Kempen, Léon C

PY - 2023/5

Y1 - 2023/5

N2 - Cribriform adenocarcinoma of salivary gland (CASG) is a rare, salivary gland tumor. In this report, we describe a case of CASG harboring a novel PPP2R2A::PRKD1 fusion. A 58-year-old female presented with an intraoral mass adjacent to the lower left third molar region. Morphological features at histological examination, immunohistochemical staining (p63+, p40-), and tumor location were indicative of CASG. However, due to the potential focal presence of a biphasic component within the tumor, RNA sequencing was performed to confirm the diagnosis. The subsequently found novel PPP2R2A::PRKD1 fusion adds to the rapidly evolving molecular landscape of salivary gland tumors. Additionally, we report that CASG may show some entrapment of pre-existent salivary gland ducts, which may be misinterpreted as tumor cells with myoepithelial differentiation.

AB - Cribriform adenocarcinoma of salivary gland (CASG) is a rare, salivary gland tumor. In this report, we describe a case of CASG harboring a novel PPP2R2A::PRKD1 fusion. A 58-year-old female presented with an intraoral mass adjacent to the lower left third molar region. Morphological features at histological examination, immunohistochemical staining (p63+, p40-), and tumor location were indicative of CASG. However, due to the potential focal presence of a biphasic component within the tumor, RNA sequencing was performed to confirm the diagnosis. The subsequently found novel PPP2R2A::PRKD1 fusion adds to the rapidly evolving molecular landscape of salivary gland tumors. Additionally, we report that CASG may show some entrapment of pre-existent salivary gland ducts, which may be misinterpreted as tumor cells with myoepithelial differentiation.

KW - Female

KW - Humans

KW - Middle Aged

KW - Adenocarcinoma/pathology

KW - Salivary Glands

KW - Transcription Factors

KW - Salivary Gland Neoplasms/pathology

KW - Biomarkers, Tumor/genetics

KW - Protein Phosphatase 2/genetics

U2 - 10.1002/gcc.23122

DO - 10.1002/gcc.23122

M3 - Article

C2 - 36625487

SN - 1045-2257

VL - 62

SP - 297

EP - 300

JO - Genes Chromosomes & Cancer

JF - Genes Chromosomes & Cancer

IS - 5

ER -

A novel PPP2R2A::PRKD1 fusion in a cribriform adenocarcinoma of salivary gland

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