A pH-Responsive Cluster Metal–Organic Framework Nanoparticle for Enhanced Tumor Accumulation and Antitumor Effect (Adv. Mater. 42/2022)

Ruoyu Cheng; Lingxi Jiang; Han Gao; Zehua Liu; Ermei Mäkilä; Shiqi Wang; Qimanguli Saiding; Lei Xiang; Xiaomei Tang; Minmin Shi; Jia Liu; Libin Pang; Jarno Salonen; Jouni Hirvonen; Hongbo Zhang; Wenguo Cui; Baiyong Shen; Hélder A. Santos

doi:10.1002/adma.202270290

A pH-Responsive Cluster Metal–Organic Framework Nanoparticle for Enhanced Tumor Accumulation and Antitumor Effect (Adv. Mater. 42/2022)

Ruoyu Cheng, Lingxi Jiang, Han Gao, Zehua Liu, Ermei Mäkilä, Shiqi Wang, Qimanguli Saiding, Lei Xiang, Xiaomei Tang, Minmin Shi, Jia Liu, Libin Pang, Jarno Salonen, Jouni Hirvonen, Hongbo Zhang, Wenguo Cui, Baiyong Shen, Hélder A. Santos

Research output: Non-textual form › Digital or Visual Products › Academic

Abstract

Tumor Therapy
A pH-responsive cluster metal–organic framework nanoparticle is developed by Wenguo Cui, Baiyong Shen, Hélder A. Santos, and co-workers in article number 2203915, based on acid-induced conversion from hydrophilicity to hydrophobicity, leading to aggregated nanoparticles. These nanoparticles inhibit tumor growth and reactivate the tumor microenvironment in both pancreatic and breast cancer models.

Original language	English
DOIs	https://doi.org/10.1002/adma.202270290
Publication status	Published - 19-Oct-2022

Keywords

cancer
metal–organic frameworks
nanoparticles
pH-responsive targeting
targeting

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Cheng, R., Jiang, L., Gao, H., Liu, Z., Mäkilä, E., Wang, S., Saiding, Q., Xiang, L., Tang, X., Shi, M., Liu, J., Pang, L., Salonen, J., Hirvonen, J., Zhang, H., Cui, W., Shen, B., & Santos, H. A. (2022). A pH-Responsive Cluster Metal–Organic Framework Nanoparticle for Enhanced Tumor Accumulation and Antitumor Effect (Adv. Mater. 42/2022). Digital or Visual Products https://doi.org/10.1002/adma.202270290

@misc{085eda9457bb4d85a32f732746f02582,

title = "A pH-Responsive Cluster Metal–Organic Framework Nanoparticle for Enhanced Tumor Accumulation and Antitumor Effect (Adv. Mater. 42/2022)",

abstract = "Tumor TherapyA pH-responsive cluster metal–organic framework nanoparticle is developed by Wenguo Cui, Baiyong Shen, H{\'e}lder A. Santos, and co-workers in article number 2203915, based on acid-induced conversion from hydrophilicity to hydrophobicity, leading to aggregated nanoparticles. These nanoparticles inhibit tumor growth and reactivate the tumor microenvironment in both pancreatic and breast cancer models.",

keywords = "cancer, metal–organic frameworks, nanoparticles, pH-responsive targeting, targeting",

author = "Ruoyu Cheng and Lingxi Jiang and Han Gao and Zehua Liu and Ermei M{\"a}kil{\"a} and Shiqi Wang and Qimanguli Saiding and Lei Xiang and Xiaomei Tang and Minmin Shi and Jia Liu and Libin Pang and Jarno Salonen and Jouni Hirvonen and Hongbo Zhang and Wenguo Cui and Baiyong Shen and Santos, {H{\'e}lder A.}",

note = "https://doi.org/10.1002/adma.202270290",

year = "2022",

month = oct,

day = "19",

doi = "10.1002/adma.202270290",

language = "English",

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Cheng, R, Jiang, L, Gao, H, Liu, Z, Mäkilä, E, Wang, S, Saiding, Q, Xiang, L, Tang, X, Shi, M, Liu, J, Pang, L, Salonen, J, Hirvonen, J, Zhang, H, Cui, W, Shen, B & Santos, HA, A pH-Responsive Cluster Metal–Organic Framework Nanoparticle for Enhanced Tumor Accumulation and Antitumor Effect (Adv. Mater. 42/2022), 2022, Digital or Visual Products. https://doi.org/10.1002/adma.202270290

TY - ADVS

T1 - A pH-Responsive Cluster Metal–Organic Framework Nanoparticle for Enhanced Tumor Accumulation and Antitumor Effect (Adv. Mater. 42/2022)

AU - Cheng, Ruoyu

AU - Jiang, Lingxi

AU - Gao, Han

AU - Liu, Zehua

AU - Mäkilä, Ermei

AU - Wang, Shiqi

AU - Saiding, Qimanguli

AU - Xiang, Lei

AU - Tang, Xiaomei

AU - Shi, Minmin

AU - Liu, Jia

AU - Pang, Libin

AU - Salonen, Jarno

AU - Hirvonen, Jouni

AU - Zhang, Hongbo

AU - Cui, Wenguo

AU - Shen, Baiyong

AU - Santos, Hélder A.

N1 - https://doi.org/10.1002/adma.202270290

PY - 2022/10/19

Y1 - 2022/10/19

N2 - Tumor TherapyA pH-responsive cluster metal–organic framework nanoparticle is developed by Wenguo Cui, Baiyong Shen, Hélder A. Santos, and co-workers in article number 2203915, based on acid-induced conversion from hydrophilicity to hydrophobicity, leading to aggregated nanoparticles. These nanoparticles inhibit tumor growth and reactivate the tumor microenvironment in both pancreatic and breast cancer models.

AB - Tumor TherapyA pH-responsive cluster metal–organic framework nanoparticle is developed by Wenguo Cui, Baiyong Shen, Hélder A. Santos, and co-workers in article number 2203915, based on acid-induced conversion from hydrophilicity to hydrophobicity, leading to aggregated nanoparticles. These nanoparticles inhibit tumor growth and reactivate the tumor microenvironment in both pancreatic and breast cancer models.

KW - cancer

KW - metal–organic frameworks

KW - nanoparticles

KW - pH-responsive targeting

KW - targeting

U2 - 10.1002/adma.202270290

DO - 10.1002/adma.202270290

M3 - Digital or Visual Products

ER -

A pH-Responsive Cluster Metal–Organic Framework Nanoparticle for Enhanced Tumor Accumulation and Antitumor Effect (Adv. Mater. 42/2022)

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Keywords

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