A physicochemical perspective on cellular ageing

Sara N. Mouton*, Arnold J. Boersma, Liesbeth M. Veenhoff

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)
46 Downloads (Pure)

Abstract

Cellular ageing described at the molecular level is a multifactorial process that leads to a spectrum of ageing trajectories. There has been recent discussion about whether a decline in physicochemical homeostasis causes aberrant phase transitions, which are a driver of ageing. Indeed, the function of all biological macromolecules, regardless of their participation in biomolecular condensates, depends on parameters such as pH, crowding, and redox state. We expand on the physicochemical homeostasis hypothesis and summarise recent evidence that the intracellular milieu influences molecular processes involved in ageing.

Original languageEnglish
Pages (from-to)949-962
Number of pages14
JournalTrends in Biochemical Sciences
Volume48
Issue number11
DOIs
Publication statusPublished - Nov-2023

Keywords

  • cell volume
  • macromolecular crowding
  • organellar crowding
  • pH
  • redox homeostasis
  • yeast

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