A pilot study in the association between Waddell Non-organic Signs and Central Sensitization

Jone Ansuategui Echeita, Mike Dijkhof, Floor Grootenboer, Peter van der Wurff, Vera Killen, Michiel Felix Reneman*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Study design: A cross-sectional observational multicenter pilot-study was performed within care as usual in three rehabilitation centers in the Netherlands.

Objective: To explore the relationship between Waddell Non-organic Signs (NOS) and Central Sensitization (CS) in patients with chronic back pain.

Summary of background data: A possible relationship between NOS and CS is theoretically plausible, but it has never been tested.

Methods: A cross-sectional observational multicenter pilot-study was performed in three rehabilitation centers in the Netherlands. Patients with chronic back pain were included. Main measures were Waddell's NOS, a battery of eight clinical tests performed during a physical examination, and Central Sensitization Inventory (CSI), a questionnaire measuring symptoms originating from CS. Analyses included Spearman correlation and univariate multiple regression analysis with NOS as dependent variable, CSI as independent, and controlled for confounders (psychosocial variables).

Results: Data of n = 56 patients (59% female, mean age 42.6 years) were obtained. Correlation between NOS and CSI was rs = 0.34 (p = 0.01). After controlling for confounders, CSI did not independently predict NOS.

Conclusion: In this pilot study, CS was moderately related to NOS, but CS did not independently contribute to NOS after controlling for confounders. The results suggest that NOS may not exclusively be non-organic tests, although questions remain. The results of this pilot study can help to develop larger studies to allow replication and more detailed analyses.

Original languageEnglish
Article number102200
Number of pages5
JournalMusculoskeletal science & practice
Volume49
DOIs
Publication statusPublished - Oct-2020

Keywords

  • Rehabilitation
  • Non-organic signs
  • Central sensitization inventory
  • Chronic pain
  • CHRONIC PAIN
  • PSYCHOLOGICAL DISTRESS
  • INVENTORY
  • INDICATORS

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