A polyethylene glycol functionalized hyaluronic acid coating for cardiovascular catheter lubrication

Prashant Sharma, Hongping Wan, Chengxiong Lin, Hans J. Kaper*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
39 Downloads (Pure)

Abstract

Catheterization is a common medical operation for cardiovascular disease diagnosis and treatment, where low friction is attained through hydrophilic lubricious coatings. But these coatings can cause iatrogenic complications when particles become lose and float freely in the blood stream. Here we present an ultra-thin coating based on polyethylene glycol (PEG) functionalized hyaluronic acid (HA). The mussel-inspired biopolymer hyaluronic acid was first conjugated to dopamine (DN) to get HADN and then poly (ethylene glycol) bis (3-amino-propyl) terminated (PBA) was used to functionalize the HADN with PEG. The reciprocating sliding ball-on-flat ex vivo model based on PU ball and porcine aorta was used to evaluate the lubrication performance and the results suggest coating of HADN with best lubrication enhancement. After 40 min friction test, the surface of aorta remained intact for HADN-PBA coated PU as compared to HADN coating and positive control (sliding against bare PU). The amount of glycocalyx, number of endothelial nuclei and intima surface of aorta for coated PU were similar to negative control (without rubbing). Besides lubrication, the high biocompatibility suggests the coating of HADN-PBA is safe and lubrication benefits to the cardiovascular catheter. (c) 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).

Original languageEnglish
Article number109080
Number of pages9
JournalMaterials & design
Volume196
DOIs
Publication statusPublished - Nov-2020

Keywords

  • HADN-PBA coating
  • Aorta
  • Friction
  • Energy dissipation
  • HYDROPHILIC POLYMER EMBOLI
  • BOUNDARY LUBRICATION
  • FRICTION TRAUMA
  • ADHESIVE
  • CATECHOL
  • CHITOSAN
  • STRESS
  • WALL

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