A Rare Case of Epstein-Barr Virus-Positive T-Cell Lymphoma in the Skin of an Immunocompromised Patient

Larissa E van Eijk; Marjolein J Koldijk; Marloes S van Kester; Arjan Diepstra; Gilles F H Diercks

doi:10.1097/DAD.0000000000002048

A Rare Case of Epstein-Barr Virus-Positive T-Cell Lymphoma in the Skin of an Immunocompromised Patient

Larissa E van Eijk, Marjolein J Koldijk, Marloes S van Kester, Arjan Diepstra, Gilles F H Diercks^*

^*Corresponding author for this work

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Abstract

Immunodeficiency-associated lymphoproliferative disorders are associated with latent infection by Epstein-Barr virus (EBV). Most cases of EBV-positive immunodeficiency-associated lymphoproliferative disorders arise from B cells, although some are of T-cell or natural killer origin. Cutaneous involvement is unusual and sporadically reported in the literature. We describe a rare case of an EBV-positive T-cell lymphoma presenting in the skin of a 32-year-old woman using adalimumab for neurosarcoidosis.

Original language	English
Pages (from-to)	E19-E22
Number of pages	4
Journal	American journal of dermatopathology
Volume	44
Issue number	2
DOIs	https://doi.org/10.1097/DAD.0000000000002048
Publication status	Published - 1-Feb-2022

Keywords

Epstein-Barr virus
immunodeficiency
cutaneous T-cell lymphoma
adalimumab
LYMPHOPROLIFERATIVE DISORDERS
EXPRESSION
ADALIMUMAB
RECEPTOR
DISEASE
CR-2
CD21

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10.1097/DAD.0000000000002048

A Rare Case of Epstein-Barr Virus–Positive T-Cell Lymphoma in the Skin of an Immunocompromised PatientFinal publisher's version, 763 KBLicence: Taverne

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title = "A Rare Case of Epstein-Barr Virus-Positive T-Cell Lymphoma in the Skin of an Immunocompromised Patient",

abstract = "Immunodeficiency-associated lymphoproliferative disorders are associated with latent infection by Epstein-Barr virus (EBV). Most cases of EBV-positive immunodeficiency-associated lymphoproliferative disorders arise from B cells, although some are of T-cell or natural killer origin. Cutaneous involvement is unusual and sporadically reported in the literature. We describe a rare case of an EBV-positive T-cell lymphoma presenting in the skin of a 32-year-old woman using adalimumab for neurosarcoidosis.",

keywords = "Epstein-Barr virus, immunodeficiency, cutaneous T-cell lymphoma, adalimumab, LYMPHOPROLIFERATIVE DISORDERS, EXPRESSION, ADALIMUMAB, RECEPTOR, DISEASE, CR-2, CD21",

author = "{van Eijk}, {Larissa E} and Koldijk, {Marjolein J} and {van Kester}, {Marloes S} and Arjan Diepstra and Diercks, {Gilles F H}",

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AU - van Eijk, Larissa E

AU - Koldijk, Marjolein J

AU - van Kester, Marloes S

AU - Diepstra, Arjan

AU - Diercks, Gilles F H

PY - 2022/2/1

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AB - Immunodeficiency-associated lymphoproliferative disorders are associated with latent infection by Epstein-Barr virus (EBV). Most cases of EBV-positive immunodeficiency-associated lymphoproliferative disorders arise from B cells, although some are of T-cell or natural killer origin. Cutaneous involvement is unusual and sporadically reported in the literature. We describe a rare case of an EBV-positive T-cell lymphoma presenting in the skin of a 32-year-old woman using adalimumab for neurosarcoidosis.

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KW - immunodeficiency

KW - cutaneous T-cell lymphoma

KW - adalimumab

KW - LYMPHOPROLIFERATIVE DISORDERS

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KW - RECEPTOR

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KW - CR-2

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