A RATIONAL BASIS FOR THE MEASUREMENT OF FREE PHENYTOIN CONCENTRATION IN CRITICALLY ILL TRAUMA PATIENTS

S ZIELMANN; F MIELCK; R KAHL; S KAZMAIER; M SYDOW; J KOLK; H BURCHARDI

A RATIONAL BASIS FOR THE MEASUREMENT OF FREE PHENYTOIN CONCENTRATION IN CRITICALLY ILL TRAUMA PATIENTS

S ZIELMANN, F MIELCK, R KAHL, S KAZMAIER, M SYDOW, J KOLK, H BURCHARDI

Research output: Contribution to journal › Article › Academic › peer-review

49 Citations (Scopus)

Abstract

Phenytoin binding to serum proteins and factors influencing protein binding were investigated in 38 critically ill trauma patients. In 24% of these patients, the free fraction of phenytoin was less-than-or-equal-to 10%, whereas in 76%, the free phenytoin fraction was increased >10%-up to 24%. Nonantiepileptic comedication, sex, or age had no influence on phenytoin binding in any of the 38 patients. Elevated free phenytoin fraction was found in those with hypoalbuminemia and hepatic and renal impairments. In these patients, the free phenytoin fraction should be measured routinely.

Original language	English
Pages (from-to)	139-144
Number of pages	6
Journal	Therapeutic Drug Monitoring
Volume	16
Issue number	2
Publication status	Published - Apr-1994

Keywords

PHENYTOIN-FREE FRACTION
CRITICALLY ILL PATIENTS
PLASMA-PROTEIN BINDING
UNBOUND PHENYTOIN
EPILEPTIC PATIENTS
DIPHENYLHYDANTOIN
SERUM
DRUGS
SEIZURES
ALBUMIN
DISEASE

Handle.net

Persistent link

Cite this

@article{c182d4519c91481c83c4008ae166541d,

title = "A RATIONAL BASIS FOR THE MEASUREMENT OF FREE PHENYTOIN CONCENTRATION IN CRITICALLY ILL TRAUMA PATIENTS",

abstract = "Phenytoin binding to serum proteins and factors influencing protein binding were investigated in 38 critically ill trauma patients. In 24% of these patients, the free fraction of phenytoin was less-than-or-equal-to 10%, whereas in 76%, the free phenytoin fraction was increased >10%-up to 24%. Nonantiepileptic comedication, sex, or age had no influence on phenytoin binding in any of the 38 patients. Elevated free phenytoin fraction was found in those with hypoalbuminemia and hepatic and renal impairments. In these patients, the free phenytoin fraction should be measured routinely.",

keywords = "PHENYTOIN-FREE FRACTION, CRITICALLY ILL PATIENTS, PLASMA-PROTEIN BINDING, UNBOUND PHENYTOIN, EPILEPTIC PATIENTS, DIPHENYLHYDANTOIN, SERUM, DRUGS, SEIZURES, ALBUMIN, DISEASE",

author = "S ZIELMANN and F MIELCK and R KAHL and S KAZMAIER and M SYDOW and J KOLK and H BURCHARDI",

year = "1994",

month = apr,

language = "English",

volume = "16",

pages = "139--144",

journal = "Therapeutic Drug Monitoring",

issn = "0163-4356",

publisher = "Lippincott Williams and Wilkins",

number = "2",

}

TY - JOUR

T1 - A RATIONAL BASIS FOR THE MEASUREMENT OF FREE PHENYTOIN CONCENTRATION IN CRITICALLY ILL TRAUMA PATIENTS

AU - ZIELMANN, S

AU - MIELCK, F

AU - KAHL, R

AU - KAZMAIER, S

AU - SYDOW, M

AU - KOLK, J

AU - BURCHARDI, H

PY - 1994/4

Y1 - 1994/4

N2 - Phenytoin binding to serum proteins and factors influencing protein binding were investigated in 38 critically ill trauma patients. In 24% of these patients, the free fraction of phenytoin was less-than-or-equal-to 10%, whereas in 76%, the free phenytoin fraction was increased >10%-up to 24%. Nonantiepileptic comedication, sex, or age had no influence on phenytoin binding in any of the 38 patients. Elevated free phenytoin fraction was found in those with hypoalbuminemia and hepatic and renal impairments. In these patients, the free phenytoin fraction should be measured routinely.

AB - Phenytoin binding to serum proteins and factors influencing protein binding were investigated in 38 critically ill trauma patients. In 24% of these patients, the free fraction of phenytoin was less-than-or-equal-to 10%, whereas in 76%, the free phenytoin fraction was increased >10%-up to 24%. Nonantiepileptic comedication, sex, or age had no influence on phenytoin binding in any of the 38 patients. Elevated free phenytoin fraction was found in those with hypoalbuminemia and hepatic and renal impairments. In these patients, the free phenytoin fraction should be measured routinely.

KW - PHENYTOIN-FREE FRACTION

KW - CRITICALLY ILL PATIENTS

KW - PLASMA-PROTEIN BINDING

KW - UNBOUND PHENYTOIN

KW - EPILEPTIC PATIENTS

KW - DIPHENYLHYDANTOIN

KW - SERUM

KW - DRUGS

KW - SEIZURES

KW - ALBUMIN

KW - DISEASE

M3 - Article

SN - 0163-4356

VL - 16

SP - 139

EP - 144

JO - Therapeutic Drug Monitoring

JF - Therapeutic Drug Monitoring

IS - 2

ER -

A RATIONAL BASIS FOR THE MEASUREMENT OF FREE PHENYTOIN CONCENTRATION IN CRITICALLY ILL TRAUMA PATIENTS

Abstract

Keywords

Handle.net

Fingerprint

Cite this