A Role for the Autonomic Nervous System in Modulating the Immune Response during Mild Emotional Stimuli

Gerda Croiset, Cobi J. Heijnen, Wim E. van der Wal, Sietse F. de Boer, David de Wied

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The role of the autonomic nervous system in the modulation of the immune response to emotional stimuli, was established in rats subjected to the passive avoidance test. An increase in splenic primary antibody response directed against SRBC was found after exposure of rats to the passive avoidance apparatus (novelty). Both local surgical denervation of the spleen and β-receptor blockade (timolol, 1 mg/kg i.p. 1 h prior to testing) prevented the increase in primary antibody response.
Original languageEnglish
Pages (from-to)419-425
Number of pages7
JournalLife Sciences
Issue number6
Publication statusPublished - 1990

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