A Role for the Autonomic Nervous System in Modulating the Immune Response during Mild Emotional Stimuli

Gerda Croiset; Cobi J. Heijnen; Wim E. van der Wal; Sietse F. de Boer; David de Wied

doi:10.1016/0024-3205(90)90085-6

A Role for the Autonomic Nervous System in Modulating the Immune Response during Mild Emotional Stimuli

Gerda Croiset, Cobi J. Heijnen, Wim E. van der Wal, Sietse F. de Boer, David de Wied

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Abstract

The role of the autonomic nervous system in the modulation of the immune response to emotional stimuli, was established in rats subjected to the passive avoidance test. An increase in splenic primary antibody response directed against SRBC was found after exposure of rats to the passive avoidance apparatus (novelty). Both local surgical denervation of the spleen and β-receptor blockade (timolol, 1 mg/kg i.p. 1 h prior to testing) prevented the increase in primary antibody response.

Original language	English
Pages (from-to)	419-425
Number of pages	7
Journal	Life Sciences
Volume	46
Issue number	6
DOIs	https://doi.org/10.1016/0024-3205(90)90085-6
Publication status	Published - 1990

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title = "A Role for the Autonomic Nervous System in Modulating the Immune Response during Mild Emotional Stimuli",

abstract = "The role of the autonomic nervous system in the modulation of the immune response to emotional stimuli, was established in rats subjected to the passive avoidance test. An increase in splenic primary antibody response directed against SRBC was found after exposure of rats to the passive avoidance apparatus (novelty). Both local surgical denervation of the spleen and β-receptor blockade (timolol, 1 mg/kg i.p. 1 h prior to testing) prevented the increase in primary antibody response.",

author = "Gerda Croiset and Heijnen, {Cobi J.} and Wal, {Wim E. van der} and Boer, {Sietse F. de} and Wied, {David de}",

note = "Relation: http://www.rug.nl/fwn/onderzoek/programmas/cbn/index Rights: University of Groningen, Centre for Behaviour and Neurosciences",

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doi = "10.1016/0024-3205(90)90085-6",

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T1 - A Role for the Autonomic Nervous System in Modulating the Immune Response during Mild Emotional Stimuli

AU - Croiset, Gerda

AU - Heijnen, Cobi J.

AU - Wal, Wim E. van der

AU - Boer, Sietse F. de

AU - Wied, David de

N1 - Relation: http://www.rug.nl/fwn/onderzoek/programmas/cbn/index Rights: University of Groningen, Centre for Behaviour and Neurosciences

PY - 1990

Y1 - 1990

N2 - The role of the autonomic nervous system in the modulation of the immune response to emotional stimuli, was established in rats subjected to the passive avoidance test. An increase in splenic primary antibody response directed against SRBC was found after exposure of rats to the passive avoidance apparatus (novelty). Both local surgical denervation of the spleen and β-receptor blockade (timolol, 1 mg/kg i.p. 1 h prior to testing) prevented the increase in primary antibody response.

AB - The role of the autonomic nervous system in the modulation of the immune response to emotional stimuli, was established in rats subjected to the passive avoidance test. An increase in splenic primary antibody response directed against SRBC was found after exposure of rats to the passive avoidance apparatus (novelty). Both local surgical denervation of the spleen and β-receptor blockade (timolol, 1 mg/kg i.p. 1 h prior to testing) prevented the increase in primary antibody response.

U2 - 10.1016/0024-3205(90)90085-6

DO - 10.1016/0024-3205(90)90085-6

M3 - Article

SN - 1879-0631

VL - 46

SP - 419

EP - 425

JO - Life Sciences

JF - Life Sciences

IS - 6

ER -

A Role for the Autonomic Nervous System in Modulating the Immune Response during Mild Emotional Stimuli

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