A Senescence-Centric View of Aging: Implications for Longevity and Disease

M Borghesan, W M H Hoogaars, M Varela-Eirin, N Talma, M Demaria*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)

Abstract

Cellular senescence is a state of stable cell cycle arrest associated with macromolecular alterations and secretion of proinflammatory cytokines and molecules. From their initial discovery in the 1960s, senescent cells have been hypothesized as potential contributors to the age-associated loss of regenerative potential. Here, we discuss recent evidence that implicates cellular senescence as a central regulatory mechanism of the aging process. We provide a comprehensive overview of age-associated pathologies in which cellular senescence has been implicated. We describe mechanisms by which senescent cells drive aging and diseases, and we discuss updates on exploiting these mechanisms as therapeutic targets. Finally, we critically analyze the use of senotherapeutics and their translation to the clinic, highlighting limitations and suggesting ideas for future applications and developments.

Original languageEnglish
Pages (from-to)777-791
Number of pages15
JournalTrends in Cell Biology
Volume30
Issue number10
Early online date13-Aug-2020
DOIs
Publication statusPublished - Oct-2020

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