A statistical multiprobe model for analyzing cis and trans genes in genetical genomics experiments with short-oligonucleotide arrays

Rudi Alberts; Peter Terpstra; Leonid V. Bystrykh; Gerald de Haan; Ritsert C. Jansen

doi:10.1534/genetics.105.045930

A statistical multiprobe model for analyzing cis and trans genes in genetical genomics experiments with short-oligonucleotide arrays

Rudi Alberts, Peter Terpstra, Leonid V. Bystrykh, Gerald de Haan, Ritsert C. Jansen

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Abstract

Short-oligonucleotide arrays typically contain multiple probes per gene. In genetical genomics applications a statistical model for the individual probe signals can help in separating ‘‘true’’ differential mRNA expression from ‘‘ghost’’ effects caused by polymorphisms, misdesigned probes, and batch effects. It can also help in detecting alternative splicing, start, or termination.

Original language	English
Pages (from-to)	1437 - 1439
Number of pages	3
Journal	Genetics
Volume	171
Issue number	3
DOIs	https://doi.org/10.1534/genetics.105.045930
Publication status	Published - 1-Nov-2005

Keywords

QUANTITATIVE TRAIT LOCI
EXPRESSION

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A statistical multiprobe model for analyzing cis and trans genes in genetical genomics experiments with short-oligonucleotide arrays
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AU - Haan, Gerald de

AU - Jansen, Ritsert C.

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AB - Short-oligonucleotide arrays typically contain multiple probes per gene. In genetical genomics applications a statistical model for the individual probe signals can help in separating ‘‘true’’ differential mRNA expression from ‘‘ghost’’ effects caused by polymorphisms, misdesigned probes, and batch effects. It can also help in detecting alternative splicing, start, or termination.

KW - QUANTITATIVE TRAIT LOCI

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A statistical multiprobe model for analyzing cis and trans genes in genetical genomics experiments with short-oligonucleotide arrays

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