A SUBLOCUS OF THE MULTICOPY MICROSATELLITE MARKER CMS1 MAPS PROXIMAL TO SPINAL MUSCULAR-ATROPHY (SMA) AS SHOWN BY RECOMBINANT ANALYSIS

G van der Steege; JM Cobben; Jan Osinga; Hans Scheffer; Gert-Jan B  van Ommen; Charles H C M Buys

doi:10.1007/BF00197416

A SUBLOCUS OF THE MULTICOPY MICROSATELLITE MARKER CMS1 MAPS PROXIMAL TO SPINAL MUSCULAR-ATROPHY (SMA) AS SHOWN BY RECOMBINANT ANALYSIS

G van der Steege^*
, JM Cobben
, Jan Osinga
, Hans Scheffer
, Gert-Jan B van Ommen
, Charles H C M Buys

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The critical region containing the spinal muscular atrophy (SMA) gene is flanked by the 5q11-q13 markers, D5S435 and D5S557, as determined by linkage analysis. Here we present the results of an analysis of a Dutch SMA family with the multicopy microsatellite marker CMS1. A crossover is revealed in the critical SMA region. We conclude that at least one of the CMS1 subloci maps proximal to the SMA gene. This reduces the minimal SMA region from approximately 1.4 Mb to 600-700 kb.

Original language	English
Pages (from-to)	589-591
Number of pages	3
Journal	HUMAN GENETICS
Volume	96
Issue number	5
DOIs	https://doi.org/10.1007/BF00197416
Publication status	Published - Nov-1995

Keywords

REGION
GENE
CONTIG

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A sublocus of the multicopy microsatellite marker CMS1 maps
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title = "A SUBLOCUS OF THE MULTICOPY MICROSATELLITE MARKER CMS1 MAPS PROXIMAL TO SPINAL MUSCULAR-ATROPHY (SMA) AS SHOWN BY RECOMBINANT ANALYSIS",

abstract = "The critical region containing the spinal muscular atrophy (SMA) gene is flanked by the 5q11-q13 markers, D5S435 and D5S557, as determined by linkage analysis. Here we present the results of an analysis of a Dutch SMA family with the multicopy microsatellite marker CMS1. A crossover is revealed in the critical SMA region. We conclude that at least one of the CMS1 subloci maps proximal to the SMA gene. This reduces the minimal SMA region from approximately 1.4 Mb to 600-700 kb.",

keywords = "REGION, GENE, CONTIG",

author = "\{van der Steege\}, G and JM Cobben and Jan Osinga and Hans Scheffer and \{van Ommen\}, \{Gert-Jan B\} and Buys, \{Charles H C M\}",

year = "1995",

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doi = "10.1007/BF00197416",

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AU - van der Steege, G

AU - Cobben, JM

AU - Osinga, Jan

AU - Scheffer, Hans

AU - van Ommen, Gert-Jan B

AU - Buys, Charles H C M

PY - 1995/11

Y1 - 1995/11

N2 - The critical region containing the spinal muscular atrophy (SMA) gene is flanked by the 5q11-q13 markers, D5S435 and D5S557, as determined by linkage analysis. Here we present the results of an analysis of a Dutch SMA family with the multicopy microsatellite marker CMS1. A crossover is revealed in the critical SMA region. We conclude that at least one of the CMS1 subloci maps proximal to the SMA gene. This reduces the minimal SMA region from approximately 1.4 Mb to 600-700 kb.

AB - The critical region containing the spinal muscular atrophy (SMA) gene is flanked by the 5q11-q13 markers, D5S435 and D5S557, as determined by linkage analysis. Here we present the results of an analysis of a Dutch SMA family with the multicopy microsatellite marker CMS1. A crossover is revealed in the critical SMA region. We conclude that at least one of the CMS1 subloci maps proximal to the SMA gene. This reduces the minimal SMA region from approximately 1.4 Mb to 600-700 kb.

KW - REGION

KW - GENE

KW - CONTIG

U2 - 10.1007/BF00197416

DO - 10.1007/BF00197416

M3 - Article

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VL - 96

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EP - 591

JO - HUMAN GENETICS

JF - HUMAN GENETICS

IS - 5

ER -

A SUBLOCUS OF THE MULTICOPY MICROSATELLITE MARKER CMS1 MAPS PROXIMAL TO SPINAL MUSCULAR-ATROPHY (SMA) AS SHOWN BY RECOMBINANT ANALYSIS

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