A sudden collapse: the disaggregation of amyloid fibres

Suzanne Couzijn; Ellen Aa Nollen

doi:10.15252/embj.2022111700

A sudden collapse: the disaggregation of amyloid fibres

Suzanne Couzijn, Ellen Aa Nollen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

A hallmark of age-related neurodegenerative diseases is the presence of highly stable protein aggregates, also known as amyloid fibres. As these fibres are strongly associated with disease, it is thought that clearance of these fibres could delay or prevent disease progression. In this issue of The EMBO Journal, Beton et al unravel how the Hsc70/DNAJB1/Apg2 disaggregase machinery disassembles amyloid fibres, using α-synuclein fibrils implicated in Parkinson's Disease as a model substrate.

Original language	English
Article number	e111700
Number of pages	3
Journal	The EMBO Journal
Volume	41
Early online date	5-Jul-2022
DOIs	https://doi.org/10.15252/embj.2022111700
Publication status	Published - 2022

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@article{17a61909c81349afaf924478cfbc2f70,

title = "A sudden collapse: the disaggregation of amyloid fibres",

abstract = "A hallmark of age-related neurodegenerative diseases is the presence of highly stable protein aggregates, also known as amyloid fibres. As these fibres are strongly associated with disease, it is thought that clearance of these fibres could delay or prevent disease progression. In this issue of The EMBO Journal, Beton et al unravel how the Hsc70/DNAJB1/Apg2 disaggregase machinery disassembles amyloid fibres, using α-synuclein fibrils implicated in Parkinson's Disease as a model substrate.",

author = "Suzanne Couzijn and Nollen, {Ellen Aa}",

note = "{\textcopyright} 2022 The Authors.",

year = "2022",

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AU - Couzijn, Suzanne

AU - Nollen, Ellen Aa

PY - 2022

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AB - A hallmark of age-related neurodegenerative diseases is the presence of highly stable protein aggregates, also known as amyloid fibres. As these fibres are strongly associated with disease, it is thought that clearance of these fibres could delay or prevent disease progression. In this issue of The EMBO Journal, Beton et al unravel how the Hsc70/DNAJB1/Apg2 disaggregase machinery disassembles amyloid fibres, using α-synuclein fibrils implicated in Parkinson's Disease as a model substrate.

U2 - 10.15252/embj.2022111700

DO - 10.15252/embj.2022111700

M3 - Article

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SN - 0261-4189

VL - 41

JO - The EMBO Journal

JF - The EMBO Journal

M1 - e111700

ER -

A sudden collapse: the disaggregation of amyloid fibres

Abstract

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