A supergene determines highly divergent male reproductive morphs in the ruff

Clemens Küpper, Michael Stocks, Judith E Risse, Natalie Dos Remedios, Lindsay L Farrell, Susan B McRae, Tawna C Morgan, Natalia Karlionova, Pavel Pinchuk, Yvonne I Verkuil, Alexander S Kitaysky, John C Wingfield, Theunis Piersma, Kai Zeng, Jon Slate, Mark Blaxter, David B Lank, Terry Burke*

*Corresponding author for this work

Research output: Contribution to journalLetterAcademicpeer-review

191 Citations (Scopus)
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Abstract

Three strikingly different alternative male mating morphs (aggressive 'independents', semicooperative 'satellites' and female-mimic 'faeders') coexist as a balanced polymorphism in the ruff, Philomachus pugnax, a lek-breeding wading bird(1-3). Major differences in body size, ornamentation, and aggressive and mating behaviors are inherited as an autosomal polymorphism(4,5). We show that development into satellites and faeders is determined by a supergene(6-8) consisting of divergent alternative, dominant and non-recombining haplotypes of an inversion on chromosome 11, which contains 125 predicted genes. Independents are homozygous for the ancestral sequence. One breakpoint of the inversion disrupts the essential CENP-N gene (encoding centromere protein N), and pedigree analysis confirms the lethality of homozygosity for the inversion. We describe new differences in behavior, testis size and steroid metabolism among morphs and identify polymorphic genes within the inversion that are likely to contribute to the differences among morphs in reproductive traits.

Original languageEnglish
Pages (from-to)79-+
Number of pages8
JournalNature Genetics
Volume48
Issue number1
DOIs
Publication statusPublished - Jan-2016

Keywords

  • PHILOMACHUS-PUGNAX
  • LINKAGE MAP
  • MATING STRATEGIES
  • SOCIAL-BEHAVIOR
  • SEQUENCING DATA
  • GENOME
  • FEMALE
  • EVOLUTION
  • LEKKING
  • DISCOVERY

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